Registration Dossier
Registration Dossier
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EC number: 217-978-1 | CAS number: 2028-63-9
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- April 1967
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 967
- Report date:
- 1967
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The test substance was i.p. injected into mice.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- But-3-yn-2-ol
- EC Number:
- 217-978-1
- EC Name:
- But-3-yn-2-ol
- Cas Number:
- 2028-63-9
- Molecular formula:
- C4H6O
- IUPAC Name:
- but-3-yn-2-ol
- Details on test material:
- purity 56.1%
other component: water
according to order sheet from Dec 2nd 1988
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: "Kisslegg" mice
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No data
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Details on exposure:
- Form of application: solution
Concentrations used: 0.5 and 1 % (w/v) (1 % was used for 100 mm3/kg bw) - Doses:
- 25, 50, 64, 80 and 100 mm3/kg
30, 59, 76, 95 and 119 mg/kg bw (calculated based on density at 20 °C = 1.189) - No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Statistics:
- No data
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 71 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: original value: LD50 ca. 60 mm3/kg bw, mg/kg bw calculated based on density at 20 °C = 1.189
- Mortality:
- Animals that died:
25 mm3/kg bw: 1 h: 0/10; 24 h: 0/10; 48 h: 0/10; 7 d: 0/10
50 mm3/kg bw: 1 h: 0/10; 24 h: 1/10; 48 h: 1/10; 7 d: 1/10
64 mm3/kg bw: 1 h: 0/10; 24 h: 2/10; 48 h: 4/10; 7 d: 5/10
80 mm3/kg bw: 1 h: 0/10; 24 h: 10/10; 48 h: 10/10; 7 d: 10/10
100 mm3/kg bw: 1 h: 0/10; 24 h: 10/10; 48 h: 10/10; 7 d: 10/10 - Clinical signs:
- In animals with high dose treatment dyspnea, apathy, seizures and hypothermia were detected. Animals treaten with 64 mm3/kg bw and lower showed only slight symptoms and some recovered.
- Body weight:
- Only recorded before application.
- Gross pathology:
- Partly fatty metamorphosis of the liver was detected in 7 of the animals that died after treatment and 2 sacrifised after 7 days.
Applicant's summary and conclusion
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