Registration Dossier
Registration Dossier
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EC number: 217-547-8 | CAS number: 1885-14-9
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Predates implementation of GLP and/or development of study guidelines, restrictions in reporting, acceptable with restrictions.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VII
- Author:
- Smyth Henry F. et al.
- Year:
- 1 969
- Bibliographic source:
- American Industrial Hygiene Association Journal, (1969) Vol. 30, Issue 5, pg. 470-476.
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VI
- Author:
- Smyth Henry F. et al.
- Year:
- 1 962
- Bibliographic source:
- American Industrial Hygiene Association Journal (1962), Vol 23, pg. 95-107
Materials and methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Phenyl chloroformate
- EC Number:
- 217-547-8
- EC Name:
- Phenyl chloroformate
- Cas Number:
- 1885-14-9
- Molecular formula:
- C7H5ClO2
- IUPAC Name:
- phenyl chloroformate
- Details on test material:
- - Name of test material (as cited in study report): Phenyl chloroformate
Constituent 1
Test animals / tissue source
- Species:
- rabbit
Test system
- Amount / concentration applied:
- Various volumes and concentrations
- Details on study design:
- Eye injury in rabbits is recorded in a 10-grade ordinal series and is based upon the degree of corneal necrosis that results from instillation of various volumes and concentrations of chemical, as detailed by Carpenter and Smyth (Am J Ophthalmol. 1946 Nov; 29(11): 1363-72). Grade 1 indicates at most a very small area of necrosis resulting from 0.5mL of undiluted chemical in the eye. Grade 5 indicates a so-called severe burn from 0.005 mL, and Grade 10 indicates a severe burn from 0.5mL of a 1% solution in water or propylene glycol.
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Corneal injury
- Score:
- 10
- Remarks on result:
- other: Grade 10 indicates a severe burn from 0.5 mL of a 1% solution
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Phenyl chloroformate induced a grade 10 (severe burn from 0.5 mL of a 1% solution) corneal injury in rabbits.
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