Registration Dossier
Registration Dossier
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EC number: 217-547-8 | CAS number: 1885-14-9
Toxicity to microorganisms
Administrative data
- Endpoint:
- toxicity to microorganisms
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP and guideline status not known, available as published report, limitations in reporting, acceptable with restrictions
Data source
Reference
- Reference Type:
- publication
- Title:
- Photobacterium phosphoreum Toxicity Data Index
- Author:
- Kaiser K.L.E. and Palabrica V.S.
- Year:
- 1 991
- Bibliographic source:
- Water Poll. Res. J. Canada, Vol. 26, No. 3, pg. 361-431 (1991)
Materials and methods
- Principles of method if other than guideline:
- Microtox test with the luminescent marine bacterium Photobacterium phosphoreum with a 5, 15 and 30 minutes exposure period.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Phenyl chloroformate
- EC Number:
- 217-547-8
- EC Name:
- Phenyl chloroformate
- Cas Number:
- 1885-14-9
- Molecular formula:
- C7H5ClO2
- IUPAC Name:
- phenyl chloroformate
- Details on test material:
- Substance: Phenyl Chloroformate
Molecular formula: C7H5Cl1O2
Molecular weight: 156.57
Purity: 97%
Constituent 1
Sampling and analysis
- Analytical monitoring:
- not specified
Test organisms
- Test organisms (species):
- Photobacterium phosphoreum
Study design
- Limit test:
- no
- Remarks on exposure duration:
- 5, 15 and 30 min exposure
Test conditions
- Test temperature:
- 15°C
- pH:
- measured or assumed to be in the range 5< pH <9
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 5 min
- Dose descriptor:
- EC50
- Effect conc.:
- 1.46 other: log(L/mmol); 5.43 mg/L
- Basis for effect:
- other: reduction of the light emission
- Duration:
- 15 min
- Dose descriptor:
- EC50
- Effect conc.:
- 1.48 other: log(L/mmol); 5.18 mg/L
- Basis for effect:
- other: reduction of the light emission relative
- Duration:
- 30 min
- Dose descriptor:
- EC50
- Effect conc.:
- 1.44 other: log(L/mmol); 5.68 mg/L
- Basis for effect:
- other: reduction of the light emission
Applicant's summary and conclusion
- Conclusions:
- The EC50 of photobacterium phosphoreum exposed to phenyl chloroformate for 30 minutes was determined to be 5.68 mg/L.
- Executive summary:
Phenyl Cholorformate was tested in the microtox test with luminescent marine bacterium photobacterium phosphoreum with a 5, 15 and 30 minutes exposure period. The EC50 (30 minutes exposure) was determined to be 5.68 mg/L.
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