Registration Dossier
Registration Dossier
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EC number: 217-547-8 | CAS number: 1885-14-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Predates implementation of GLP and/or development of study guidelines, restrictions in reporting, acceptable with restrictions.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VII
- Author:
- Smyth Henry F. et al.
- Year:
- 1 969
- Bibliographic source:
- American Industrial Hygiene Association Journal, (1969) Vol. 30, Issue 5, pg. 470-476.
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VI
- Author:
- Smyth Henry F. et al.
- Year:
- 1 962
- Bibliographic source:
- American Industrial Hygiene Association Journal (1962), Vol 23, pg. 95-107
Materials and methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Phenyl chloroformate
- EC Number:
- 217-547-8
- EC Name:
- Phenyl chloroformate
- Cas Number:
- 1885-14-9
- Molecular formula:
- C7H5ClO2
- IUPAC Name:
- phenyl chloroformate
- Details on test material:
- - Name of test material (as cited in study report): Phenyl chloroformate
Constituent 1
Test animals
- Species:
- rabbit
- Details on test animals or test system and environmental conditions:
- albino rabbits, no further data available
Test system
- Type of coverage:
- open
- Preparation of test site:
- clipped
- Amount / concentration applied:
- 0.01 mL undiluted sample
- Observation period:
- 24 hours
- Number of animals:
- 5
- Details on study design:
- Primary skin irritation on rabbits is recorded in a 10-grade ordinal series and is based upon the severest reaction that develops on the clipped skin of each of five albino rabbits within 24 hours of the uncovered application of 0.01 mL of undiluted sample or of solutions in water, propylene glycol, or acetone. Grade 1 indicates no irritation and Grade 2 the least visible capillary injection from the undiluted chemical. Grade 6 indicates necrosis when undiluted and Grade 10 indicates necrosis from a 0.01% solution.
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Primary skin irritation
- Score:
- 6
- Remarks on result:
- other: Grade 6 indicates necrosis when chemical is undiluted applied to the skin.
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Phenyl chloroformate induced in rabbits, after 24 hours exposure, a primary skin irritation grade 6 (necrosis when chemical is applied undiluted to the skin).
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