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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Reference:
Composition 0
Qualifier:
no guideline available
Principles of method if other than guideline:
Consensus model in Test v4.2
Model prediction report is attached in IUCLID
GLP compliance:
no
Test material information:
Composition 1
Specific details on test material used for the study:
SMILES: OC1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]1O
Test organisms (species):
Daphnia magna
Test type:
other: QSAR prediction
Total exposure duration:
48 h
Key result
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
10 617.09 mg/L
Remarks on result:
other: QSAR prediction
Validity criteria fulfilled:
yes
Conclusions:
48-hour LC50 (Daphnia magna): 10617.09 mg/L
Executive summary:

The consensus model in Times v4.2 was used to predict the acute toxicity to Daphnia magna. The 48-hour LC50 in fathead minnow was predicted to be 10617.09 mg/L. Additional supporting documentation is provided in the prediction report attached in IUCLID.

Description of key information

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
10 617.09 mg/L

Additional information