Registration Dossier

Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro cytogenicity / chromosome aberration study in mammalian cells
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1981

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Human lymphocytes were exposed to lead acetate alone (100 nM to 1 mM) or in combination with cadmium acetate or zinc acetate for three hours and chromosome abberations and gaps were examined.
GLP compliance:
not specified
Type of assay:
other: in vitro mammalian chromosome aberration test (migrated information)

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Test results
Species / strain:
other: Human lymphocytes
Metabolic activation:
without
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified
Vehicle controls validity:
valid
Untreated negative controls validity:
valid
Positive controls validity:
not examined
Remarks on result:
other: Test system: all strains/cell types tested

Any other information on results incl. tables

Lead acetate exposure alone or in combination with cadmium and/or zinc did not increase the frequency of chromosome abberations or gaps at any concentration tested.

Applicant's summary and conclusion

Conclusions:
Interpretation of results: negative
Executive summary:

Human lymphocytes were exposed to lead acetate alone (100 nM to 1 mM) or in combination with cadmium acetate or zinc acetate for three hours and chromosome abberations and gaps were examined. Lead acetate exposure alone or in combination with cadmium and/or zinc did not increase the frequency of chromosome abberations or gaps at any concentration tested.