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EC number: 234-853-7
CAS number: 12036-76-9
Multiple Regression Results for Recumbent Length at 33 months*
* PbB, blood lead concentration
** 1=male, 2=female
*** 1=white, 2=black
This report is a follow-up of an earlier study of the effects of low to
moderate prenatal and postnatal lead exposure on children's growth in
stature. Two hundred thirty-five subjects were assessed every 3 months
for lead exposure (blood lead level) and stature (recumbent length) up
to 33 months of age. Fetal lead exposure was indexed by maternal blood
lead level during pregnancy. The adverse effects of lead on growth
during the first year of life were reported previously. This analysis
covers essentially the second and third years of life. The results
indicate that mean blood lead level during this period was negatively
associated with attained height at 33 months of age (P=.002). This
association was, however, evidenced only among those who had mean blood
lead levels greater than the cohort median (>/= 10.77ug/dl) during the 3
to 15 month interval. The results also suggest that the effect of lead
exposure (both in utero as well as during the first year of life) are
transient provided that subsequent exposure to lead is not excessive. It
appears that maintaining an average blood lead level of 25ug/dl or more
during the second and third year of life was detrimental to the child's
attained stature at 33 months of age. Approximately 15% of this cohort
expserienced these levels of lead exposure. Potential deficiencies in
control for lifestyle confounders could account for this finding.
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