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EC number: 239-268-0
CAS number: 15214-89-8
signs observed in the animals dosed at 1500 mg/kg included increased
respiratory rate (50%), watery feces (28%), soft feces (17%), and
wheezing (1%). Mean body weights of the dose groups were not
significantly different from the vehicle control group at any time
point. As is illustrated in Table 1 below, the test article did not
produce statistically significant increases (p<0.05) in the percentage
of cells with aberrations at any dose, time period or for either sex,
compared to control values. Positive control animals treated with
cyclophosphamide (30 mg/kg) demonstrated an increase in the frequency of
damaged cells which was statistically significant at the study threshold
of p<0.05. Thus, the positive and negative controls demonstrated the
reliability of the assay to detect chromosomal aberrations.
% cells with
% cells with
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