Registration Dossier

Administrative data

Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2007
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Well documented report of guideline study conducted according to GLP.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2007
Report Date:
2007

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 112 (Dissociation Constants in Water)
GLP compliance:
yes (incl. certificate)

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material: ATBS
- Physical state: white powder
- Analytical purity: 99.4 %
- Lot/batch No.: 061202
- Expiration date of the lot/batch: 30 june 2007
- Storage condition of test material: Room temperature in the dark
- Other: Date received: 18 January 2007

Results and discussion

Dissociating properties:
yes
Dissosciation constant
pKa:
2.4
Temp.:
20 °C
Remarks on result:
other: same value for the three tests

Any other information on results incl. tables

The pKa values for each of the samples A, B and C was determined to be 2.4. The mean pKa value was determined to be 2.4

Applicant's summary and conclusion

Conclusions:
The pKa of ATBS was found to be 2.4