Registration Dossier

Administrative data

Endpoint:
acute toxicity: other routes
Adequacy of study:
other information
Reliability:
1 (reliable without restriction)

Data source

Reference
Title:
No information
Author:
Heimann, K.G. & Thyssen, J.: Diuron active ingredients: Studies on acute toxicity,|Bayer AG, Wuppertal, Germany|unpublished report no. 11710, (April 11, 1983)

Materials and methods

Principles of method if other than guideline:
LD50 calculated according Litchfield & Wilcoxon (1949)
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
IUCLID4 Test substance: as prescribed by 1.1 - 1.4

Test animals

Species:
rat
Strain:
Wistar
Sex:
female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
other: distilled water with Cremophor (5 drops/10 mL)
Doses:
25, 50, 250, 315, 400 or 500 mg/kg bw
No. of animals per sex per dose:
10

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
368 mg/kg bw

Any other information on results incl. tables

RS-Freetext:
At the lowest dose level, no clinical signs were noted. Higher dose  levels revealed behavioural, respiratory and motility disorders. Some  animals exhibited a narcosis-like state and lying on side or stomach.  Signs were noted between 18 min (high dose levels) and 2 hours at lower  doses following administration. 
Upon necropsy in dead animals distended, pathy lungs, patchy livers,  kidneys and spleens were noted. Sacrificed animals showed no gross  changes in organs.
Mortalities occurred at 315 mg/kg and above within 2 days.
Mortality: 315 mg, 2/10; 400 mg, 7/10; 500 mg, 9/10

Applicant's summary and conclusion

Conclusions:
CL-Freetext:
LD50 = 368 (317 - 427) mg/kg bw by the intraperitoneal route