Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

 A reliable Guinea Pig Maximisation Test (GPMT) test was conducted in compliance with OECD Guideline 406 on Diuron. Female guinea-pigs were intradermally and epicutaneo

usly induced before being challenged with a 50% Diuron solution in saline. No skin reaction on the basis of erythema and oedema (sensitization rate 0%) was observed. A 50% solution of Diuron did not provoke skin sensitization (Sharp 1997).

A skin sensitisation study was performed according to the Magnusson-Kligman method using Freund’s complete adjuvant technique to evaluate the sensitisation potential of test item Diuron Technical.

The mean of the scores were 0.10 and 0.00 according to the 24th and 48th hour observations. In the control group the mean of the scores were 0.10 and 0.00.Since the reactions in the test group did not markedly exceed in the control group, no evidence of delayed contact hypersensitivity was found in this assay


Migrated from Short description of key information:
All the available studies on Diuron showed that the substance is not a skin sensitiser.

Justification for classification or non-classification

The available data on sensitisation is conclusive but not sufficient for classification according to directives DSD (67/548/EEC) or CLP (1272/2008/EC).