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Toxicological information

Specific investigations: other studies

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Administrative data

Endpoint:
mechanistic studies
Adequacy of study:
other information
Reliability:
1 (reliable without restriction)
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Title:
No information
Author:
Schmidt, W.M. & Karbe, E.: Diuron - Study for toxicity to Wistar rats with special attention to urothelial alterations, |Bayer AG, Wuppertal, Germany,|unpublished report No. 15936, (July 20, 1987)

Materials and methods

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
Wistar
Sex:
male

Administration / exposure

Route of administration:
other: oral in feed
Vehicle:
other: diet
Frequency of treatment:
2, 4, 12 or 26 weeks (plus week recovery after 4 week treatment and 8 week recovery after 26 weeks)
Doses / concentrations
Remarks:
Doses / Concentrations:
2500 ppm
Basis:

No. of animals per sex per dose:
10
Control animals:
yes, concurrent vehicle
Details on study design:
Type: other: evaluation of urothelial alterations

Results and discussion

Any other information on results incl. tables

Result: local irritation of the urothelial tract may be the cause of the lesions

Applicant's summary and conclusion

Conclusions:
CL-Freetext:
The early appearance of hyperplasia and other alterations in the urinary bladder may indicate local irritation of the urothelial tract as the cause of the lesions induced in male Wistar rats treated with Diuron at 2500 ppm for 2 to 26 weeks