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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
supporting study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Poorly documented orientating trial, insufficient for assessment of inhalation toxicity.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1971
Report Date:
1971

Materials and methods

Principles of method if other than guideline:
Duration of exposure: 2 hours
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material: Sorbic acid

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
TEST ANIMALS - type of rabbit: yellow-silver

Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
nose only
Vehicle:
other: air
Details on inhalation exposure:
Administration: as aerosol (saturated)
Particle size: not stated
Type or preparation of particles: dust generation
Duration of exposure:
2 h
Concentrations:
no data
No. of animals per sex per dose:
Number of animals: 6 (3 per group)
Control animals:
no
Details on study design:
- Duration of observation period following administration: 7 d p.a.
- Examinations: behaviour, mortality

Results and discussion

Effect levels
Remarks on result:
other: No mortality was observed after 7 days. No abnormal behaviour was observed after 7 days.
Mortality:
No mortality was observed after 7 days.
Clinical signs:
No abnormal behaviour was observed after 7 days.

Applicant's summary and conclusion

Conclusions:
The extrapolation from sorbic acid to potassium sorbate is considered not to be restricted in any way, since the determinant of potential toxicity is on the "sorbate" anion.