Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

  • EC / List name: 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
  • IUPAC name: 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-1,2-dihydropyridin-2-one; 2-aminoethan-1-ol
  • Other names
EC / List no.:
272-574-2
CAS no.:
68890-66-4
Index number:
Molecular formula:
C16H30N2O3
SMILES:
NCCO.CC(CC1=CC(C)=CC(=O)N1O)CC(C)(C)C
InChI:
InChI=1/C14H23NO2.C2H7NO/c1-10-6-12(15(17)13(16)8-10)7-11(2)9-14(3,4)5;3-1-2-4/h6,8,11,17H,7,9H2,1-5H3;4H,1-3H2 AuxInfo=1/0/N:9,15,14,16,17,5,10,4,12,6,11,2,3,13,1,7,8;19,18,21,20/E:(3,4,5);/rA:21NCCCCCOOCCCCCCCCCCCON/rB:s1;s1;s3;d-2;d-4s5;d3;s1;s6;s2;s10;s11;s12;s13;s11;s13;s13;;s18;s18;s19;/rC:2.5715,.337,0;1.1021,.337,0;3.3878,1.6567,0;2.5715,2.9629,0;.2448,1.6703,0;1.0612,2.9765,0;4.9117,1.6567,0;3.3063,-1.0235,0;.3264,4.2554,0;.3264,-1.0101,0;-1.2246,-1.0101,0;-1.9455,-2.3026,0;-3.4832,-2.3569,0;-4.2586,-3.7175,0;-1.9591,.3097,0;-4.2313,-1.051,0;-2.7076,-3.6903,0;9.0917,.3572,0;10.4521,-.3639,0;9.0917,1.9082,0;10.4657,-1.9014,0;
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
9
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

There is no harmonised classification and there are no notified hazards by manufacturers, importers or downstream users for this substance.

Breakdown of all 0 C&L notifications submitted to ECHA

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

  • Ss
  • Sr

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 12 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Classification Labelling & Packaging (CLP)

Harmonised C&L:
Notification:

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 100 - 1 000 tonnes per year.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: cosmetics and personal care products and perfumes and fragrances.

Other release to the environment of this substance is likely to occur from: indoor use as processing aid.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

Other release to the environment of this substance is likely to occur from: indoor use as processing aid.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

This substance is used in the following products: cosmetics and personal care products.

ECHA has no public registered data on the types of manufacture using this substance.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

Other release to the environment of this substance is likely to occur from: indoor use as reactive substance.

This substance is used in the following products: cosmetics and personal care products and perfumes and fragrances.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation, mixing in open batch processes, transfer of substance into small containers, laboratory work and closed, continuous processes with occasional controlled exposure.

Release to the environment of this substance can occur from industrial use: formulation of mixtures.

This substance is used in the following products: cosmetics and personal care products and perfumes and fragrances.

This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: closed batch processing in synthesis or formulation, mixing in open batch processes, transfer of substance into small containers, closed processes with no likelihood of exposure, transfer of chemicals at dedicated facilities, production of mixtures or articles by tabletting, compression, extrusion or pelletisation and laboratory work.

Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites and in the production of articles.

This substance is used in the following activities or processes at workplace: closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation, transfer of substance into small containers and laboratory work.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: use only outdoors or in a well-ventilated area; avoid release to the environment; wash parts of the body (as specified by manufacturer/supplier)in contact with substance thoroughly after handling; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier; avoid breathing the dust, fume, gas, mist, vapours or spray.

Response statements

In case of incident: If skin irritation occurs: Get medical advice/attention. If in eyes: rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • Clariant Produkte (Deutschland) GmbH, Am Unisys-Park 1 65843 Sulzbach am Taunus Germany
  • GKG Goldmann Kunststoffe GmbH & Co. KG, Schillerstr. 33609 Bielefeld Germany
  • KUMAR ORGANIC PRODUCTS LIMITED, 3 , St.Mary’s Road, LU1 3JA Luton Bedfordshire United Kingdom
  • Procter & Gamble Blois S.A.S., 163/165 quai Aulagnier 92600 ASNIERES SUR SEINE France
  • Procter & Gamble Marketing Romania, 9-9A Dimitrie Pompei Blvd. Sector 2 BUCURESTI Romania
  • Procter & Gamble – Rakona s.r.o., Ottova 402 269 32 Rakovnik Czech Republic
  • Procter and Gamble Operations Polska Sp. z o. o., Zabraniecka Street 20 03-872 Warsaw Poland
  • RSI ChemRep Europe Ltd (K002), 27-30 Merchants Quay Merchants House 8 Dublin Ireland
  • SpecChem GmbH, Robert Bosch Strasse 29a 88131 Lindau Germany
  • Sustainability Support Services (Europe) AB, Markaskälsvägen 6 22647 Lund Sweden
  • [Confidential], [Confidential]

Other names

  • (RS)-1-HYDROXY-4-METHYL-6-(2,4,4-TRIMETHYLPENTYL)-2(1H)-PYRIDINONE ETHANOLAMINE (1:1)
  • -
  • 1-Hydroxy-4-methyl-6(2,4,4-trimethylpentyl)2-pyridon monoethanolamine salt
  • 1-hydroxy-4-methyl-6-(2,4,4-trimethylpently)pyridin-2-(1H)-one compound with 2-aminoethanol (1:1)
  • 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-1,2-dihydropyridin-2-one; 2-aminoethan-1-ol
  • 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-(1H)pyridinone, 2-aminoethanol salt
  • 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one - 2-aminoethanol (1:1)
  • 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
  • 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one,compound with 2-aminoethanol (1:1)
  • 1-hydroxy-4methyl-6-(2,4,4-trimethylphenyl)pyridine-2(1H)-one, compound with 2-aminoethanol(1:1)
  • 2-aminoethanol; 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2-one
  • 2-aminoethanol;1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2-one
  • 2-amminoetanolo; 1-idrossi-4-metil-6-(2,4,4-trimethylpentyl) pyridin-2-one
  • Octopirox
  • Piroctone Olamine
  • 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
  • Picroctone Olamine
  • Piroctone olamine

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 2 studies submitted
  • 2 studies processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [2]
C Form
Powder (50%), Other (50%) [2]
C Odour
Faint (50%), Other (50%) [2]
C Substance type
Organic (100%) [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Physical state at 20°C and 1013 hPa
Solid (100%)

Melting/freezing point

Study results
  • 3 studies submitted
  • 1 study processed
R Melting / freezing point
132 °C @ 101.3 kPa [1]

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Melting / freezing point at 101 325 Pa
132 - 136 °C

Boiling point

Study results
  • 2 studies submitted
  • 1 study processed
R Boiling point
130 - 135 °C [1]

Type of Study provided
Studies with data
Key study 1 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Boiling point at 101 325 Pa
135 - 235 °C

Density

Study results
  • 3 studies submitted
  • 1 study processed
R Relative density
1.1 @ 21.5 °C [1]

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Relative density at 20°C
1.1

Vapour pressure

Study results
  • 4 studies submitted
  • 1 study processed
R Vapour pressure
0 - 0.001 Pa @ 20 - 50 °C [3]

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Vapour pressure
0 - 0 Pa @ 20 - 25 °C

Partition coefficient

Study results
  • 2 studies submitted
  • 2 studies processed
R Log Pow
1.05 - 3.86 @ 20.5 - 25 °C and pH 4 [2]

Type of Study provided
Studies with data
Key study 1 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Log Kow (Log Pow)
1.05 - 3.86 @ 20 - 25 °C

Water solubility

Study results
  • 3 studies submitted
  • 2 studies processed
R Water solubility (mass/vol.)
19 - 500 000 mg/L @ 10 - 30 °C and pH 4 - 9 [10]

Type of Study provided
Studies with data
Key study 1 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Water solubility
400 - 50 000 mg/L @ 20 - 25 °C

Solubility in organic solvents / fat solubility

Study results
  • 1 study submitted
  • 1 study processed
R N-octanol
37.5 g/L @ 20 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Solubility in organic solvents at 20 °C
37.5 mg/L

Surface tension

Study results
  • 2 studies submitted
  • 1 study processed
R Surface tension
38.7 mN/m @ 400 mg/L and 25 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Surface tension at 20 °C
38.7 mN/m @ 400 mg/L

Flash point

Study results
  • 2 studies submitted
  • 1 study processed
R Flash point
161.9 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Flash point at 101 325 Pa
161.9 °C

Auto flammability

Study results
  • 2 studies submitted
  • 1 study processed
R Autoflammability / self-ignition
430 °C @ 101.3 kPa [1]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Flammability

Study results
  • 2 studies submitted
  • 1 study processed
C Interpretation of results
Non flammable (100%) [1]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Flammability
Not classified (50%), Non flammable (50%)

Explosiveness

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Oxidising
Non oxidising (50%), No (50%)

Oxidation reduction potential

Data not provided by the registrant

pH

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Dissociation constant

Study results
  • 2 studies submitted
  • 1 study processed
C Dissociating properties
Yes (100%) [1]
R Dissociation constant
5.85 - 5.91 @ 20 °C [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
pKa at 20 °C
5.9 - 7.4

Viscosity

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Hydrolysis

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half-life for hydrolysis
5 days @ 25 °C

Phototransformation in water

Study results
  • 1 study submitted
  • 1 study processed
R Dissipation Half-life (DT50)
13.2 - 1 296 min [3]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half-life in water
34 min

Phototransformation in soil

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Biodegradation in water - screening tests

Study results
  • 10 studies submitted
  • 1 study processed
C Interpretation of results
Readily biodegradable (100%) [1]

Type of Study provided
Studies with data
Key study 3
Supporting study 7
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Biodegradation in water
Under test conditions no biodegradation observed (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Half-life in freshwater
37.5 days @ 25 °C
Half-life in freshwater sediment
11.25 months @ 25 °C

Biodegradation in soil

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half-life in soil
75 days @ 25 °C

Bioaccumulation: aquatic / sediment

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation Factor (BCF) - L/kg ww
20.42 L/kg ww

Bioaccumulation: terrestrial

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Adsorption/desorption

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Koc at 20°C
1 845.01

Henrys law constant (H)

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 2 summaries submitted
  • 2 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 1.25 - 2.6 µg/L (2)
Intermittent releases (freshwater) 12.5 - 18 µg/L (2)
Marine water 125 - 260 ng/L (2)
Intermittent releases (marine water) 1.25 µg/L (1)
Sewage treatment plant (STP) 5.83 - 8.34 mg/L (2)
Sediment (freshwater) 235 - 5 000 µg/kg sediment dw (2)
Sediment (marine water) 23.5 - 500 µg/kg sediment dw (2)
Hazard for Air
Air No hazard identified (2)
Hazard for Terrestrial Organism
Soil 46.3 - 10 400 µg/kg soil dw (2)
Hazard for Predators
Secondary poisoning 3.3 mg/kg food (1)

Short–term toxicity to fish

Study results
  • 7 studies submitted
  • 2 studies processed
P/RResults
LC50 (4 days) 1.89 - 9.123 mg/L [2]
LC50 (72 h) 2.1 mg/L [1]
LC50 (48 h) 2.57 mg/L [1]
LC50 (24 h) 2.89 mg/L [1]
LC50 (2 h) 5 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 4
Weight of evidence 1 1
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
LC50 for freshwater fish
1.89 - 9.12 mg/L

Long–term toxicity to fish

Study results
  • 2 studies submitted
  • 1 study processed
P/RResults
NOEC (28 days) 40.102 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 / LC10 or NOEC for freshwater fish
40 mg/L

Short–term toxicity to aquatic invertebrates

Study results
  • 3 studies submitted
  • 1 study processed
P/RResults
EC50 (48 h) 1.8 mg/L [1]
EC50 (24 h) 2.18 mg/L [1]
EC100 (48 h) 5 mg/L [1]
EC100 (24 h) 5 mg/L [1]
EC10 (48 h) 1.29 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence 1
Other 1
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
EC50 / LC50 for freshwater invertebrates
1.25 - 1.8 mg/L

Long–term toxicity to aquatic invertebrates

Study results
  • 2 studies submitted
  • 2 studies processed
P/RResults
NOEC (21 days) 128 - 21 309 µg/L [2]

Type of Study provided
Studies with data
Key study 1 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 / LC10 or NOEC for freshwater invertebrates
128 µg/L

Toxicity to aquatic algae and cyanobacteria

Study results
  • 3 studies submitted
  • 2 studies processed
P/RResults
EC50 (72 h) 3.504 - 10.8 mg/L [3]
EC10 (72 h) 6 - 6.3 mg/L [2]

Type of Study provided
Studies with data
Key study 1 1
Supporting study
Weight of evidence 1
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
EC50 for freshwater algae
3.5 - 10.8 mg/L
EC10 or NOEC for freshwater algae
6.3 mg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 5 studies submitted
  • 3 studies processed
P/RResults
EC50 (3 h) 583 mg/L [1]
IC50 (24 h) 32 - 64 mg/L [2]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence 2 1
Other 1
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
EC50 for microorganisms
83.459 - 583 mg/L

Sediment toxicity

Study results
  • 2 studies submitted
  • 2 studies processed
P/RResults
NOEC (28 days) 250 mg/kg sediment dw [1]
NOEC (4 days) 250 mg/kg sediment dw [1]
LOEC (28 days) 500 mg/kg sediment dw [1]
EC50 (28 days) 527 mg/kg sediment dw [1]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 / LC10 or NOEC for freshwater sediment
250 mg/kg sediment dw

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 3 studies submitted
  • 2 studies processed
P/RResults
NOEC (56 days) 1 g/kg soil dw [1]
NOEC (14 days) 1 g/kg soil dw [1]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Long-term EC10 / LC10 / NOEC
1 g/kg soil dw

Toxicity to terrestrial arthropods

Study results
  • 2 studies submitted
  • 1 study processed
P/RResults
NOEC (28 days) 250 mg/kg soil dw [1]
EC50 (28 days) 800 mg/kg soil dw [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Long-term EC10 / LC10 / NOEC
250 mg/kg soil dw

Toxicity to terrestrial plants

Study results
  • 2 studies submitted
  • 1 study processed
P/RResults
NOEC (21 days) 500 - 1 000 mg/kg soil dw [3]
EC25 (21 days) 1 g/kg soil dw [3]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Long-term EC10 / LC10 / NOEC
500 mg/kg soil dw

Toxicity to soil microorganisms

Study results
  • 2 studies submitted
  • 1 study processed
P/RResults
EC10 (28 days) 104 mg/kg soil dw [1]
EC50 (28 days) 255 mg/kg soil dw [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Long-term EC10 / NOEC
104 mg/kg soil dw

Toxicity to birds

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 12.3 mg/m³ repeated dose toxicity
Acute /short term: Low hazard (no threshold derived)
Local Effects
Long-term: Low hazard (no threshold derived)
Acute /short term: Low hazard (no threshold derived)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 3.5 mg/kg bw/day repeated dose toxicity
Acute /short term: Medium hazard (no threshold derived)
Local Effects
Long-term: Medium hazard (no threshold derived)
Acute /short term: Medium hazard (no threshold derived)
EYE Exposure
High hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1.85 mg/m³ repeated dose toxicity
Acute /short term: Low hazard (no threshold derived)
Local Effects
Long-term: Low hazard (no threshold derived)
Acute /short term: Low hazard (no threshold derived)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1.25 mg/kg bw/day repeated dose toxicity
Acute /short term: Medium hazard (no threshold derived)
Local Effects
Long-term: Medium hazard (no threshold derived)
Acute /short term: Medium hazard (no threshold derived)
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1.25 mg/kg bw/day repeated dose toxicity
Acute /short term: Low hazard (no threshold derived)
EYE Exposure
High hazard (no threshold derived)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 2
Supporting study 5
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal absorption
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Absorption values
Dermal: 1 %

Acute toxicity

Study results
oral
  • 5 studies submitted
  • 5 studies processed
P/RResults
LD50 8 100 mg/kg bw (rat) [2]
LD50 5 000 - 24 280 mg/kg bw (mouse) [2]
LD50 4 000 mg/kg bw (dog) [1]
M/CInterpretations of results
Practically nontoxic [2]

Type of Study provided
oral
Studies with data
Key study 2
Supporting study
Weight of evidence 3
Other
Data waiving
no waivers
inhalation
  • 3 studies submitted
  • 2 studies processed
P/RResults
LC50 (4 h) 4.9 - 37.161 mg/L air (rat) [2]
M/CInterpretations of results
Practically nontoxic [1]

inhalation
Studies with data
Key study 1
Supporting study
Weight of evidence 1 1
Other
Data waiving
no waivers
dermal
  • 3 studies submitted
  • 2 studies processed
P/RResults
LD50 2 000 mg/kg bw (rat) [1]
LD50 2 195.52 mg/kg bw (rabbit) [1]
M/CInterpretations of results
Practically nontoxic [1]

dermal
Studies with data
Key study 1
Supporting study
Weight of evidence 1 1
Other
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Oral route:
No adverse effect observed LD50 8 100 mg/kg bw
Inhalation route:
No adverse effect observed LC50 37 160 mg/m³
Dermal route:
No adverse effect observed LD50 2 195.52 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 10 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 8
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: eye
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Skin
Adverse effect observed (irritating)
Eye
Adverse effect observed (irritating)

Sensitisation

Study results
Study data: skin
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: respiratory
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No adverse effect observed (not sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 7 studies submitted
  • 4 studies processed
P/RResults
NOEL (rat): 55 - 210 mg/kg bw/day [3]
NOEL (dog): 100 mg/kg bw/day [2]

Type of Study provided
Study data: oral
Studies with data
Key study 5
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Study data: inhalation
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Study data: inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Study data: dermal
  • 7 studies submitted
  • 3 studies processed
P/RResults
NOEL (rat): 100 - 500 mg/kg bw/day [1]
NOEL (rat): 2 mg/cm² per day [1]
NOEL (rabbit): 59.706 mg/kg bw/day [1]

Study data: dermal
Studies with data
Key study 2
Supporting study 2
Weight of evidence 2 1
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Oral route - systemic effects:
No adverse effect observed NOAEL 250 mg/kg bw/day (subchronic, rat)
Dermal route - systemic effects:
No adverse effect observed NOAEL 59.706 mg/kg bw/day (subacute, rabbit)

Genetic toxicity

Study results
Study data: in vitro
  • 12 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 3
Supporting study 2
Weight of evidence 4 3
Other
Data waiving
no waivers
Study data: in vivo
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 3
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Toxicity - InVitro
No adverse effect observed (negative)
Toxicity - InVivo
No study available

Carcinogenicity

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to reproduction

Study results
Study data: reproduction
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 2
Supporting study 3
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: developmental
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: other studies
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Effect on fertility
Oral route:
No adverse effect observed NOAEL 250 mg/kg bw/day (subacute, rat)
Effect on developmental toxicity
Oral route:
No adverse effect observed NOAEL 100 mg/kg bw/day (subacute, rat)

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant