Registration Dossier
Registration Dossier
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EC number: 272-574-2 | CAS number: 68890-66-4
Endpoint summary
Administrative data
Description of key information
The acute toxicity of Octopirox was investigated following oral exposure in rats and dogs as well as after dermal and inhalation exposure was in rats. Independent of the species and/or sex tested and exposure route used, Octopirox was practically non-toxic.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 8 100 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 4 900 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
The cumulative data amassed during the toxicological evaluations demonstrate that Octopirox has an extremely low order of toxicity. According to the results from acute studies, Octopirox is practically non-toxic (LD50 = 8100 ,g/kg body weight orally in female rats; LD50 > 4000 mg/kg body weight orally in female beagle dogs; LD50 > 2000 mg/kg body weight dermally in female rats; LC50 > 4.9 mg/L inhalative in rats).
Justification for classification or non-classification
Based on the results from acute toxicity studies, Octopirox is not subject to labelling and classification requirements.
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