Registration Dossier
Registration Dossier
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EC number: 272-574-2 | CAS number: 68890-66-4
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
In this study Octopirox was found to be toxic to Daphnia magna after 48 h at concentrations of 1.58 mg/L and higher. The EC50 (48h) was 1.80 mg/L (1.62 - 1.92 mg/L). The NOEC after 48 h was 0.889 mg/L. The LOEC after 48 h was 1.58 mg/L
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 1.8 mg/L
Additional information
Octopirox forms chelate complex with two and three valent ions like Fe(II), Fe(III), Al(III). If the test organism is dependent from such ions during the test e.g. algae, daphnia, this will influence growth and survival. As these ions mentioned before are ubiquitous in the sewer, the sewage treatment plant and in the environment e.g. river Octopirox forms immediately these chelate complexes. In order to avoid interference with the necessary test conditions in the Guideline tests and to avoid unrealistic test test settings e.g. pronounced toxicity by interference with essential ions, the aquatic ecotoxicity tests were carried out in river water where the ions mentioned above are present.
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