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EC number: 201-240-0
CAS number: 79-97-0
Review of toxicokinetic data as required by Annex VIII of REACH. The
available test data do not permit extensive conclusions concerning
absorption, metabolism or excretion to be conclusively drawn. Acute
toxicity (via the oral route) and repeated oral administration results,
no mortality was observed although treatment related systemic effects
Repeated oral administration of the test substance (in an OECD 421
study) to rats provided paternal NOAEL of 250 mg/kg/day. The clinical
signs evident at the top dose indicated that some absorption and
distribution of the test substance can be expected. At 62.5 and 250
mg/kg/day, no adverse effects were noted and it is possible that
bioelimination through normal metabolic and excretory pathways allows
some removal of the test substance, with the potential for these
pathways to be overwhelmed at the top dose.
The substance was determined to be a skin sensitiser based on the
results of 3 in chemico/in vitro skin sensitisation assays
(weight-of-evidence assessment), indicating that the test substance
potentially has the ability to pass through the dermal layers of the
skin or produce systemic effects; it was noted that loss of fur was
evident in the oral reproductive screening test.
Based on the relatively low Log Kow values (<4.5) and low aqueous
solubility of the test substance, bioaccumulation of the test substance
is expected to be low.
No in vivo mutagenicity/clastogenicity data are available. It
was observed in an in vitro chromosome aberration assay that the test
substance was clastogenic to human lymphocytes with the possible
indication that test substance is absorbed and not excreted without any
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