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EC number: 701-122-3
CAS number: 106185-75-5
Two oral acute toxicity studies are available showing LD50 > 2000 mg/kg bw.One dermal acute toxicity study is available showing LD50 > 4600 mg/kg bw.
Table 1: BODY WEIGHT - Individual values (g)
D15 – D1
Sex : Male
Sex : Female
Sex : Male
An acute oral toxicity study (limit test)
with the test item was conducted in 10 albino Sprague Dawley rats
(5/sex/dose) under GLP conditions following OECD guideline 401. The test
substance was administered through oral gavage at the single dose of
2000 mg/kg bw. Animals were observed daily for clinical signs and
mortality for 14 days. Body weights were taken prior to the
administration of the test material, D4, D8 and D15. Six hours following
administration of the test substance, a slight piloerection was observed
in all animals. 1 hour after administration, a decrease in motor
activity and muscle tone was noticed in one male and one female. There
was no mortality. All animals were subjected to necropsy at the end of
the observation period. No gross lesions were found.
Therefore, oral LD50 of the test substance
is higher than 2000 mg/kg bw. According to directive 67/548/EEC and CLP
regulation (EC) n° 1272/2008, the test substance should not be
In a GLP acute oral toxicity study (limit
test) performed according to OECD guideline 401, no mortality and no
clinical signs related to treatment were observed, therefore LD50
was higher than 2000 mg/kg bw.
In an older study, also performed according
to OECD guideline 401, the test item tested at 5000 mg/kg bw led to the
following clinical signs without death: pilo-erection, abnormal
body carriage (hunched posture), abnormal gait (waddling), diarrhea and
increased salivation. LD50 was higher than 5000 mg/kg
In an acute dermal toxicity study (limit
test), no mortality was observed in rats exposed to 5 mL/kg bw
(corresponding to 4.6 g/kg bw).
As LD50 for oral and dermal acute
toxicity are higher than 2000 mg/kg bw, the test item is not classified
according to Directive 67/548/EEC and CLP Regulation (EC) n° 1272/2008.
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