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EC number: 701-122-3
CAS number: 106185-75-5
There were no studies available in which the toxicokinetic properties of (2E)-ethyl-4-(2,2,3-trimethylcyclopent-3-en-1-yl) but-2-en-1 -ol were investigated
There were no studies available in which the
toxicokinetic properties of (2E)-ethyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)
but-2-en-1-ol were investigated.
but-2-en-1-ol is a liquid with a molecular weight of 208, is slightly
soluble in water (25.83 mg/L at 20°C) and is highly lipophilic (log Kow
In an oral repeated dose toxicity
range-finding experiment, male and female rats exposed for 14 days
showed increased liver weight in both sexes and a slight increase in
kidney weight in females. These effects show clear signs of oral
bioavailability of the test material.
Also, in a 13-week repeated dose toxicity
study conducted acording to OECD guideline 408, males and/or females
exposed by diet to the substance showed slight non-adverse and
reversible changes in haematological parameters (erythrocyte and
haemoglobin concentrations, prothrombin time and haematocrit),
biochemical parameters (urea,
blood urea nitrogen and creatinine concentrations, glucose, alkaline
phosphatase, albumin concentrations and albumin/globulin ratio),
associated with increases in liver and/or kidney weights. These
observations are thought to be indicative of adaptations of
metabolism/excretion in the liver and kidneys, with absence of
degenerative or functional change in liver or kidneys.
together, these observations clearly show absorption, systemic exposure
and metabolism/excretion by liver and kidneys via oral route.
but-2-en-1-ol has a molecular weight lower than 500 and a high lipophily
(log Kow > 4) with a low volatility (vapour
pressure < 0.1 Pa), dermal bioavailability is highly probable. Dermal
penetration is confirmed by an acute dermal toxicity study where
clinical sign such as diarrhea was observed, showing clear systemic
effects after dermal exposure.
but-2-en-1-ol has log Kow=4.4 at 35°C which is below 4.5, the limit of
criterion for bioaccumulation, therefore it is considered that the
substance has a low bioaccumulation potential.
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