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EC number: 701-122-3
CAS number: 106185-75-5
Daily observation of ocular reactions
In an eye irritation study conducted
similarly to OECD guideline 405, one healthy male rabbit of the New
Zealand White strain was exposed to 100 µL of undiluted test item in one
of the eyes. The eyes were assessed for conjunctival responses 15 min
after treatment and corneal, conjunctival and iridial responses were
observed at 1, 2, 3, 4 and 6 days after treatment.
Instillation of the test item resulted in
loss of small area of corneal epithelium with slight corneal swelling,
slight iritis and moderate conjunctivitis with copious discharge. The
irritation completely resolved within 6 days. Mean individual scores at
24, 48 and 72 hours after exposure for the animal were 1 for corneal
score, 0.33 for iris score, 1.33 for conjunctivae score and 1 for
Based on the results obtained with one
animal, the test item is classified as ‘R36 Irritating to eyes’
according to Directive 67/548/EEC and as ‘Irritating to eye (Category
2)’ according to CLP Regulation (EC) n° 1272/2008.
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