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EC number: 701-122-3
CAS number: 106185-75-5
Table 1: Mortality
of Bluegill Sunfish (Lepomis macrochirus) during a 96-hour exposure to
the test item under flow-through test conditions
Cumulative number dead
Mean measured conc. (mg a.i/L)
Treatment mortality (%)
Table 2: Calculated
LC50 values, based upon mean measured concentrations, for a
96-hour flow-through exposure of Bluegill sunfish (Lepomis macrochirus)
to the test item
Exposure period (hour)
LC50(mg a.i/L; ppm)
95-percent confidence limits
* NC: The slope could not be calculated (NC)
using the Spearman-Karber method
In a 96-h acute toxicity study,
Bluegill sunfish (Lepomis macrochirus) were exposed to the test
item at measured concentrations of 0 (control, vehicle control), 0.38,
0.49, 0.99, 2.2, 6 mga.i./L under flowthrough conditions. The 96-h LC50
was 1.1 mg a.i./L. The NOEC value, based on mortality/sublethal
effects, was 0.49 mg a.i./L. Sublethal effects of loss of equilibrium
and irregular respiration were observed in the groups exposed to
concentrations > 0.99 mg a.i/L of the test item.
This toxicity study is classified as
acceptable and satisfies with the guidelines requirements for OECD 203,
fish acute toxicity study.
Test organism size/age (mean wet
weight or length): Bluegill Sunfish (Lepomis macrochirus); mean
weight = 0.618 ± 0.347 g; mean length = 30 ± 4.1 mm
Test Type (Flowthrough, Static, Static
LC50: 1.1 mg
a.i./L 95% C.I.: 0.89 to 1.2 mg a.i./L}
NOEC: 0.49 mg a.i./L}
Endpoint Effected: mortality
The substance exhibits a LC50 for freshwater fish of 1.1 mg/L.
Two experimental data and one QSAR data are
available to determine the short-term toxicity to aquatic invertebrates.
Kranzfelder, J.A, 1999
In an acute aquatic toxicity study performed
according to the EPA OPPTS 850.1075 guideline, groups of Bluegill
sunfish (Lepomis macrochirus) were exposed to Super Radjanol at
concentrations of 0, 0.38, 0.75, 1.5, 3.0 or 6.0 mg/L (nominal) for 96
hours under flow-through conditions. Mortality, behaviour and
morphological aberrations were observed at 6, 24, 48, 72 and 96 hours.
Mortalities (96-hour exposure) at 0, 0.38, 0.49, 0.99, 2.2 or 6.0 mg/L
(mean of concentrations measured at 0, 48 and 96 h) were 0, 0, 0, 45,
100 and 100%, respectively. Calculated LC50 at 24, 48, 72 and 96 hours
were 3.2, 1.5, 1.4, 1.1 mg/L respectively, based on measured
concentration of test item. This toxicity study is classified as
acceptable and satisfies the guideline requirements for an acute fish
toxicity study. This study is given a reliability score of 2 (reliable
with restrictions) since the test method is considered as an alternative
to the EU test method and the OECD test guideline.
A QSAR prediction was performed to assess
the acute toxicity of the test item
2-ethyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-(2E)-buten-1-ol to fish.
This QSAR has been validated to be compliant with the OECD
recommendations for QSAR modeling (OECD, 2004) and predicts the endpoint
value which would be expected when testing the substance under
experimental conditions in a laboratory following Guideline for Testing
of Chemicals No. 203, "Fish Acute Toxicity Test" (1), referenced as
Method C.1 of Commission Regulation No. 440/2008 (2). The criterion
predicted was the LC50(Median Lethal Concentration), a statistically
derived concentration which is expected to cause mortality in 50% of
test animals within a period of 96 hours. The QSAR is based on validated
data for a training set of 67 chemicals derived from 96-hour test on
fish, for which the concentrations of the test item had been determined
by chemical analyses over the test period.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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