Registration Dossier
Registration Dossier
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EC number: 249-854-8 | CAS number: 29797-40-8
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: No OECD guideline or GLP defined. Limited data documentation; No LD 50 defined, no particle size defined.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
- Principles of method if other than guideline:
- 5 animals/sex, whole body exposition, post exposure observation time: 14 d
- GLP compliance:
- no
- Test type:
- other: acute inhalation toxicology study in rats
- Limit test:
- no
Test material
- Reference substance name:
- Dichloromethylbenzene
- EC Number:
- 249-854-8
- EC Name:
- Dichloromethylbenzene
- Cas Number:
- 29797-40-8
- Molecular formula:
- C7H6Cl2
- IUPAC Name:
- (dichloromethyl)benzene
- Details on test material:
- no data about ingredients of the mixture
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Wistar Albino rats TNO/W 74
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- not specified
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 3 - 7 h
- Concentrations:
- 200 l air/h where conveyed through 50g test substance
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
Results and discussion
Any other information on results incl. tables
inhalation for 7 h (20 degree Celsius): no mortality;
inhalation for 7 h (30 degree Celsius): no mortality;
inhalation for 3 h (95 degree Celsius): 20 % of the females died;
inhalation for 7 h (95 degree Celsius): 3/10 animals died
intoxication symtoms: behaviour disturbance, difficulty of
breathing, agitation, sedation, irritation of the mucous membranes
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- No LC50 was defined.
- Executive summary:
In an acute inhalation study in male and female Wistar rats the test substance was vapoured dynamicly at temperatures of 20°C, 30°C and 95°C in a Time-saturation-test. 200 l air/h where conveyed through 50g test substance. The results were following:
inhalation for 7 h (20°C) : no mortality;
inhalation for 7 h (30°C): no mortality;
inhalation for 3 h (95°C): 20 % of the females died;
inhalation for 7 h (95°C): 3/10 animals died.
Intoxication symtoms: behaviour disturbance, difficulty of breathing, agitation, sedation, irritation of the mucous membranes.No LC50 was defined.
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