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Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2002
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
other: European Commission, "Particle Size Distribution, Fibre Length and Diameter Distribution" Guidance Document, ECB/TM/February 1996.
Deviations:
not specified
GLP compliance:
yes
Type of method:
Laser scattering/diffraction
Type of distribution:
volumetric distribution
Mass median aerodynamic diameter:
16.7 µm
Percentile:
D50
Mean:
< 16.7 µm
St. dev.:
1.499
Percentile:
D10
Mean:
< 1.5 µm
St. dev.:
0.428
Percentile:
D90
Mean:
< 40.1 µm
St. dev.:
6.591

A solubility test showed, that the test item is both: sparingly soluble and well dispersible in water containing 0.2 g/l sympatens SHO/400. For the particle size distribution measurement the test item was dispersed two times in pre-saturated water

The particle size distribution was found to range from approximately 0.3 µm to 100 µm.

The mass median diameter was determined to be 16.7 µm.

Conclusions:
The particle size distribution of test substance was measured to be MMD=16.7 µm
Executive summary:

In this EC guideline study conducted to GLP standards, the test material (EC 438-340-0) was determined to have a particle size distribution of MMD=16.7 µm.

Description of key information

Study conducted to recognised testing guidelines with GLP.

Additional information

MMD= 16.7µm
D10= 1.5µm
D90= 40µm

Particle size distribution ranges from approx. 0.3 to 100µm.