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EC number: 438-340-0
CAS number: 119344-86-4
The objective of this study was to
determine the Dissociation Constants of Omnirad 379.
The Dissociation Constants is
calculated at 5.94 and 3.49.
The determination of the dissociation
constant (pKa) of TK 11005 (CGI 113) was performed according to the OECD
Guideline For Testing of Chemicals, No. 112, "Dissociation Constants in
Water", adopted May 12, 1981. During this study the titration method was
During the titration of the test item with
0.01 mol/l sodium hydroxide solution, the conversion could not be
reached. The progression of the titration curve for the test item during
alkalic titration is the same as for the blank solution. Therefore, no
pKa value could be calculated for alkalic titration and the
determination of the dissociation constant was repeated by titration
with 0.01 mol/l hydrochloric acid.
The results of four determinations of the
dissociation constant (pKa) of TK 11005 (CGI 113) are presented in
Tables 1 to 4.
For the titration with 0.01 mol/l
hydrochloric acid, the following pKa values of the protonated test item
were calculated according to Albert and Sergeant 
Mean ± Std. dev. = 6.22 ± 0.05
The pKa value determined might vary to a
low extent to that equivalent in pure water. The addition of acetone was
necessary due to the relatively low water solubility of TK 11005 (CGI
113). The acetone content should not influence the dissociation
behaviour of TK 11005 (CGI 113).
In the present study, the dissociation
constant (pKa) of the protonated form of TK 11005 (CGI 113) in water was
determined by titration with 0.01 mol/l hydrochloric acid. The
dissociation constant was found to be:
pKa= 6.22 at 20°C
The dissociation constant of test item was
determined by titration with 0.01 mol/l hydrochloric acid.
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