Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 255-449-7 | CAS number: 41583-09-9
Specific investigations: other studies
Administrative data
Link to relevant study record(s)
- Endpoint:
- endocrine system modulation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scientific publication with appropriate description of the method.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The aim of this study was to assess the estrogenic activities of environmentally relevant chemicals including melamine.
Method according to Nishikawa et al. The yeast two-hybrid system is based on the ligand-dependent interaction of two proteins, a hormone receptor and a coactivator, and hormonal activity is detected by ß-galactosidase activity. - GLP compliance:
- not specified
- Type of method:
- in vitro
- Species:
- other: Saccharomyces cerevisiae Y 190
- Route of administration:
- other: in vitro assay
- Duration of treatment / exposure:
- Exposure period: 4 hour(s)
- Details on study design:
- Yeast Two-Hybrid Assay.
Reference
Melamine showed no estrogenic activity within the Yeast Two-Hybrid assay.
Description of key information
Melamine showed no estrogenic activity within the Yeast Two-Hybrid assay.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
