Registration Dossier
Registration Dossier
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EC number: 255-449-7 | CAS number: 41583-09-9
Toxicity to terrestrial plants
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
In the absence of toxicity data for soil organisms, the equilibrium partitioning method may be applied to assess the hazard to soil organisms. The PNECsoil can be estimated by the equilibrium partitioning method from the PNECaquatic, especially in case the substance is not strongly adsorptive, as is melamine. This method is used to estimate the PNECsoil. In addition, melamine has a low toxicity to mammals and aquatic organisms, not leading to a classification. The chemical safety assessment therefore does not include a risk assessment and therefore do not indicate the need to investigate further the effects of the substance and/or degradation products on terrestrial organisms. Moreover the absence of chronic or long-term effects in aquatic organisms up to the substance solubility limit, or of acute effects within the solubility range above 10 mg/L (melamine meets both criteria) can be used as part of a weight of evidence argument to modify/waive the data requirements of Annex IX and X." A WoE approach is applied, considering a read across to the low aquatic short and long-term toxicity of melamine, the low adsorption to soil, the proposed studies with invertebrates and soil microorganisms, andthe low plant toxicity detected in the supporting studies.
In addition, no data of the target substance were available. A weight of evidence approach with the read across source substance melamine (CAS 108-78-1) is applied.
Only 2 short reports are available (please refer section 13 for the read across justification). They indicate a low toxicity of melamine to terrestrial plants.
- Koch, 1986 (DSM): The toxicity to plants (root growth reduction) was determined after 96 hours of exposure of barleyn wheat and radish to melamine. The EC50 was ca. 530 mg/L groundwater and above.
- Jansen, 1982 (DSM): The toxicity of melamine (in Melafslik) was tested in peas and beans. The toxicity limit was at ca. 170 mg/kg soil dw
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