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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Administrative data

Endpoint:
bioaccumulation in aquatic species: fish
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Database source, only few details are provided, but data base is created and used by the Japanese authorities, and is therefore considered to be sufficiently reliable.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
2010

Materials and methods

Principles of method if other than guideline:
Bioconcentration test
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Melamine; 108-78-1.

Test organisms

Test organisms (species):
Cyprinus carpio

Study design

Route of exposure:
aqueous
Test type:
flow-through
Total exposure / uptake duration:
6 wk

Test conditions

Nominal and measured concentrations:
2 mg/L and 0.2 mg/L.
Reference substance (positive control):
not specified

Results and discussion

Bioaccumulation factoropen allclose all
Type:
BCF
Value:
< 0.38
Remarks on result:
other: Conc.in environment / dose:2 ppm
Type:
BCF
Value:
< 3.8
Remarks on result:
other: Conc.in environment / dose:0.2 ppm

Applicant's summary and conclusion

Conclusions:
A weight of evidence approach is applied, based on the 3 reported studies (2 times Lech 1984 and Nite 2010).
The bioconcentration factor is low in each case.
Executive summary:

Cyprinus carpio was exposed for 6 weeks to melamine at concentrations of 2 and 0.2 ppm. The bioconcentration factors are

BCF < 0.38 at 2 ppm.

BCF < 3.8 at 0.2 ppm.

Judgement: low bioconcentration.