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EC number: 255-449-7 | CAS number: 41583-09-9
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
A read-across from the source substance CAS 108-78-1, melamine, is justified. The experimental determinations of the bioconcentration factor BCF in 3 species of fish are available. In these studies (Lech, 1984 and Nite, 2010) no bioaccumulation of melamine is expected as the determined bioconcentration factors in fish are < 1 (only at 0.2 ppm the BCF = 3.8). Based on this result, the test substance does not accumulate in organisms. The calculated logPow of -3 at 25 °C (see section 4.7) of the test substance is below the threshold value of 4 (according to GHS criteria) and thus, accumulation in organisms of the test substance is not expected.
Key value for chemical safety assessment
- BCF (aquatic species):
- 3.8 dimensionless
Additional information
No data with the target substance are available. According to Annex IX, Section 9.3.2 column 2 of REACH Regulation (EC) No 1907/2006 a study on bioaccumulation need not to be conducted, if the substance has a low potential for bioaccumulation (for instance a log Kow ≤ 3). The calculated log Kow of -3 of the test substance is below the threshold value of 4 (according to GHS criteria) and thus, accumulation in organisms of the test substance is not expected.
In addition, as the substance is a water soluble salt of phosphate, effects can be read-across from the cation, which is likely to have the more important effects. In biological systems, phosphate is an abundant in cells and body fluids. In ecological terms, because of its important role in biological systems, phosphate is a highly sought-after resource. Thus, read-across from the read across source substance melamine CAS 108-78-1 is justified. Please refer section 13 for read across justification.
Three experimental determinations of the bioconcentration factor BCF in 3 species of fish were reported (2 times Lech 1984; Nite 2010). The BCF was < 1 in each case, except for the Nite 2010 study with the lower concentration of 0.2 ppm in water, where the BCF was 3.8.
Moreover an older and less reliable estimation (ECETOC 1983) of the BCF, based on the water solubility of melamine, yielded a BCF = 15.
Altogether it is unlikely that melamine could bioaccumulate to a relevant degree.
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