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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Incomplete report; Inadequate details of study design and results; Composition uncertain.
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1958
Report Date:
1958

Materials and methods

Test guideline
Qualifier:
no guideline available
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Type:
Constituent
Details on test material:
67.2% active (SDS 67%)

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
No data

Test system

Vehicle:
unchanged (no vehicle)
Controls:
other: The left eye served as a control
Amount / concentration applied:
0.1 ml
Observation period (in vivo):
14 days
Number of animals or in vitro replicates:
one
Details on study design:
Exactly 0.1 ml of the undiluted test material was instilled into the conjunctival sac of the right eye of a single albino rabbit. The left eye served as a
scoring control. One. 24. 48. 72, 96 hours, and 7 days after the instillation. the cornea. iris. and palpebral conjunctiva were graded individually for
eye irritation and injury according to a standard scoring system. Zero score indicates no irritation whatever while the maximum score (110) indicates maximal irritation and injury to all three ocultar tissues.

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
animal #1
Max. score:
110
Reversibility:
not reversible
Irritant / corrosive response data:
The results indicated undiluted Test Material to be maximally irritating to occular tissues. Although not included in the scores there
was little or no improvement noted in the condition of the treated eye after 14 days.

Any other information on results incl. tables

Eye irritation scores

Time

1 hours

24 hours

48 hours

72 hours

96 hours

7 days

Maximum

Possible Score

Cornea

60

60

80

60

80

80

80

Iris

10

10

10

10

10

10

10

Conjunctiva

14

15

20

20

20

20

20

Total

84

86

110

110

110

110

110

Applicant's summary and conclusion

Interpretation of results:
Category 1 (irreversible effects on the eye) based on GHS criteria
Remarks:
Migrated information
Conclusions:
The results indicated undiluted Test Material to be maximally irritating to ocular tissues. Although not included in the scores. there was little or no improvement noted in the condition of the treated eye after 14 days.
Executive summary:

The product tested was evaluated for its effects when instilled into rabbit eyes. The results indicates severely irritation to rabbit eyes. The maximum irritation score was 110 out of a possible 110.

Label Requirements under GHS: Symbol "Corrosion"; Signal word "Danger"; Hazard statement H318: "Causes serious eye damage"