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EC number: 276-038-9 | CAS number: 71808-53-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 12.1 µg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 4.14 µg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 1.21 µg/L
- Assessment factor:
- 100
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 1.09 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 61.4 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 6.14 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 30.6 mg/kg soil dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
PNECs are based on the following data for the test substance:
Test type |
Results |
Microorganisms, activated sludge |
3h-EC10respiration: 10.9 mg/L |
Short-term studies |
|
Daphnia magna |
21d-EC50: 0.465 mg/L |
Danio rerio |
96h-LC50: 1.84 mg/L |
Pseudokirchneriella subcapitata |
72h-ErC50: 0.414 mg/L |
Chronic studies |
|
Pseudokirchneriella subcapitata |
72h-ErC10: 0.121 mg/L |
Daphnia magna |
21d-NOECreprod: 0.268 mg/L |
The PNEC freshwater has been derived on the basis of aquatic toxicity data determined in tests employing river water. The river water data are based on nominal concentrations. The rationale behind the use of river water tests is the strong sorption to organic matter and test vessels of the substance. The derived PNECbulkwill be compared to the PECbulk(which includes the fraction adsorbed onto suspended matter) in the risk characterisation. The same approach has been used for other cationic surfactants.
The PNECaquatic bulk is calculated using the assessment factor proposed by the REACH guidance. As long-term NOECs from species representing two trophic levels are available (algae and daphnia) an assessment factor of 50 may be used. However based on the observed lower toxicity to fish in acute tests, it is considered unlikely that long term fish toxicity will be critical for the PNEC derivation. Hence any additional toxicity testing with fish will not add scientific value to the ecotoxicity profile other than for obtaining a lower assessment factor. It is therefore concluded that for scientific reasons and in accordance to REACH legislation further testing on fish has to be avoided for reasons of animal welfare and that based on the weight of evidence available on the ecotoxicity data it is justified to apply a safety factor of 10 for the derivation of the PNECaquatic,bulk. With the same motivation, AF of 100 has been used for the derivation of PNEC marine.
No tests were performed with sediment organisms or terrestrial organisms. The PNECs for those compartments were derived using the equilibrium partitioning theory and Koc. All relevant substance characteristics were entered into EUSES version 2.1.2 to produce PNECsediment for the freshwater and marine compartment as wel as PNECsoil. Since PNECfreshwater is based on the bulk concentration present in surface water, a recalculation was necessary to PNECfreshwater,dissolved before application of the equilibrium partitioning method. The following equation was used:
PNECfreshwater,dissolved = PNECfreshwater,bulk/ (1+ Kpsusp*SUSPwater*10-6)
where PNECfreshwater,bulk = 12.1 µg/L,
Kpsusp= 5496 L/kg (EUSES) and
SUSPwater = 15 mg/L.
The resulting PNECfreshwater,dissolved = 11.2 µg/L. PNECfreshwater,sediment, PNECmarine, sediment and PNECsoil were then calculated with EUSES employing PNECfreshwater,dissolved of 11.2 µg/L.
The PNEC for sediment is than calculated applying the EPM:
PNECsed = Ksusp-water* PNECaquatic dissolved* 1000 * 1 / RHOsusp
Where: PNECaquatic dissolved = 11.2 µg/L
Ksusp-water = 1374 m3/m3
RHOsusp = 1150 kg/m3(TGD, equ. 18)
PNECsed-EPM = 13.35 mg/kg ww
= 61.4 mg/kg dw
Despite of the low bioaccumulation potential a PNECoral can be calculated using the acute NOAEL of 18.75 mg/kg bw a.i.
PNECoral = (NOAEL * Convmammal)/AF = (18.75*20)/300 = 1.25 mg/kg
Convmammal = 20 (Rat > 6 weeks)
AF = 300 (acute study)
Conclusion on classification
For classification purposes Ecotoxicity, Biodegradability and Bioconcentration have to be considered.
Ecotoxicity
Due to intrinsic properties of quaternary ammonium ethoxylates, river water ecotoxicity tests deliver reproducible test results with limited uncertainty. As river water has a mitigating effect on ecotoxicity due to sorption of the quaternary ammonium ethoxylates to DOC and suspended matter, a factor of 10 should be applied to the L(E)Cx and NOEC to correct for the lower ecotoxicity observed. Algae are in general the most sensitive species and are therefore the basis for classification of the quaternary ammonium, C12-18-alkylbis(hydroxyethyl)methyl, chloride. It should be noted that the 21day-daphnia EC50 is included in the table below for classification purposes as a worst-case for acute toxicity in river water tests.
The classification is based on the following aquatic toxicity data for the test substance:
Test type |
Results |
Correction for river water with factor 10 |
|
|
|
Short-term studies |
|
|
Danio rerio |
96h-LC50: 1.84 mg/L |
|
Daphnia magna |
21d-EC50immobility: 465 µg/L |
46.5 µg/L |
Pseudokirchneriella subcapitata |
72h-ErC50: 413.5 µg/L |
41.4 µg/L |
Chronic studies |
|
|
Daphnia magna |
21d-NOECreprod: 268 µg/L |
26.8 µg/L |
Pseudokirchneriella subcapitata |
72h-ErC10: 121 µg/L |
12.1 µg/L |
Biodegradability
The substance is rapidly biodegradable in the environment as demonstrated with a Closed bottle test according to OECD TG 301 D. The biodegradation percentage was 70% after 28 days.
Bioaccumulation potential
The very low log Kow of -0.12 suggests that the substance has a low bioaccumulation potential.
Conclusion classification according to CLP Regulation 1272/2008
Based on the results of the acute aquatic toxicity (values < 1 mg/L) the substance is classified with Category Acute 1 (M-factor 10).
Based on the results of the chronic aquatic toxicity ( 0.01 < ErC10 < 0.1 mg/L) and since the substance has a low bioaccumulation potential and is rapidly biodegradable, the substance is classified with Category Chronic 2 (no M-factor).
Classification according to 67/548/EEC (DSD)
Acute aquatic toxicity is < 1 mg/l and the substance is rapidly biodegradable and has a low bioaccumulation potential (log Kow of -0.12). Therefore the substance is classified with N:R50.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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