Oxirane, 2-methyl-, (2R)-

Repeated dose toxicity: inhalation

Administrative data

Endpoint:

repeated dose toxicity: inhalation

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

supporting study

Study period:

2002

Reliability:

2 (reliable with restrictions)

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

review article or handbook

Title:

Unnamed

Year:

2002

Materials and methods

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

propylene oxide

IUPAC Name:

propylene oxide

Constituent 2

Reference substance name:

Methyloxirane

EC Number:

200-879-2

EC Name:

Methyloxirane

Cas Number:

75-56-9

IUPAC Name:

2-methyloxirane

Results and discussion

Target system / organ toxicity

Critical effects observed:

not specified

Applicant's summary and conclusion

Conclusions:

In rats and mice, repeated inhalation exposure to propylene oxide for 2 years produced chronic irritation of the nasal epithelium, with such effects being only marginal in nature at 30 ppm. However, concentrations of 100 ppm and above produced epithelial damage. In a 4 -week study in rats, small and reversible increases in nasal epithelium irritation occurred at 525 ppm propylene oxide. There is some evidence to indicate neurotoxicity in rats at a relatively high exposure level of 1,500 ppm after 7 weeks of exposure. No signs of neurotoxicity were observed in rats exposed to 300 ppm for 24 weeks.