Registration Dossier

Administrative data

Endpoint:
repeated dose toxicity: inhalation
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Study period:
2002
Reliability:
2 (reliable with restrictions)
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
2002

Materials and methods

GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
In rats and mice, repeated inhalation exposure to propylene oxide for 2 years produced chronic irritation of the nasal epithelium, with such effects being only marginal in nature at 30 ppm. However, concentrations of 100 ppm and above produced epithelial damage. In a 4 -week study in rats, small and reversible increases in nasal epithelium irritation occurred at 525 ppm propylene oxide. There is some evidence to indicate neurotoxicity in rats at a relatively high exposure level of 1,500 ppm after 7 weeks of exposure. No signs of neurotoxicity were observed in rats exposed to 300 ppm for 24 weeks.