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A skin irritation study in animals performed to regulatory standards is not available. A relatively old study in rabbits indicated that application of undiluted or 10-20% aqueous propylene oxide may cause signs of skin irritation within minutes and scar formation with more lengthy exposures. In a more recent study, in which propylene oxide may have evaporated from the test sites, no skin irritation was observed. Overall, it appears that propylene oxide liquid may cause local irritation on contact with the skin. In light of eye irritation following exposure to propylene oxide vapour, it is considered that the liquid also has the potential to produce eye irritation. Classification according to Annex I of Directive 67/548/EC is proposed as follows: R36/37/38 Irritating to Eyes, Respiratory System and Skin. 

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