Registration Dossier

Administrative data

Endpoint:
repeated dose toxicity: oral
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Study period:
2002
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Cited experiments were summarized in the European Chemicals Bureau Methyloxirane (Propylene Oxide) Risk Assessment Report. The original studies were not reviewed.
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
2002

Materials and methods

GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
Following repeated daily oral doses by gavage in 5 rats per sex per goups (18 doses in 24 days), a slight reduction in body weight gain, gastric irritation and slight liver damage were observed at 300 mg/kg. No effect was noted at 100 or 200 mg/kg (Rowe et al., 1956).

Dunkelberg (1982) administered 0, 15 and 60 mg/kg propylene oxide by gavage, twice weekly for 150 weeks to groups of 50 female Sprague-Dawley rata. Survival of the propylene oxide-treated animals did not differ significantly from vehicle controls. The principal findings were reactive changes (epithelial hyperplasia) in the squamous epithelium and associated neoplasms of the forestomach.