Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2002
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The result was obtained from a collection of reliable data which has been subject to peer-review and in which the original data sources are traceable.

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
2002

Materials and methods

Principles of method if other than guideline:
According to Deneer et al. (1988, quoted in above report), a slow stirring method was employed to minimise the formation of emulsions and the test was conducted in triplicate at room temperature. Analysis was by gas-liquid chromatography (GLC).
GLP compliance:
no
Type of method:
other:
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
Test material was racemate from both R(+) and S(-) propylene oxide. This endpoint is not measured / determined with enantio-selective sensors.
Therefore the R(+) value is identical to the racemate endpoint.

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
>= 0.03 - <= 0.085
Remarks on result:
other: Test at room temperature
Details on results:
The experimental values obtained are in reasonably close agreement, (within the error margins of the experimental method).

Any other information on results incl. tables

A number of calculated log Kow values are quoted in IUCLID, ranging from -0.27 (Lipnick et al., 1987) to 0.35 (references from citation above).

Applicant's summary and conclusion

Conclusions:
A partition coefficient of 0.03 - 0.085 was obtained at room temperature for the propylene oxide in two reliable studies. A log KOW of 0.055 shall be
used for the exposure assessment.