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EC number: 203-161-7
CAS number: 103-95-7
Results for Cyclamen Aldehyde
derived EC3 = 22.3%
The murine local lymph node assay (LLNA) assesses skin
sensitization potential as a function of proliferative responses induced
in lymph nodes draining the site of topical exposure to test chemical.
It has been shown that interpolation of LLNA dose-response data to
define the concentration of test chemical required to induce a 3-fold
stimulation of proliferation (EC3) offers the prospect of a quantitative
index of the relative potency of a contact allergen. Initial studies
have demonstrated that there exists a strong (inverse) correlation
between EC3 values and contact allergenic potency in humans. Thus,
materials with a low EC3 value were more potent contact allergens in
humans. However, it is necessary to examine a wide range of allergens to
demonstrate that such correlations are generally true.
Thus, in the present study, 10 aldehydes (including
Cyclamen Aldehyde) of varying degrees of allergenicity in man were
evaluated in the LLNA and their EC3 values derived. Formaldehyde was
regarded as the strongest allergen in man and also had the lowest EC3
value, 0.35% (equivalent to 0.93% formalin).
In contrast, the extremely weak allergen vanillin and the
non-sensitizer ethyl vanillin both had EC3 values of >50%. For the
remaining 7 aldehydes, there was a close similarity between what is
judged to be their rank order of allergenicity in humans and EC3 values
derived from analysis of LLNA data. These results support further the
utility of EC3 determinations in the LLNA as a measure of the relative
potency of a contact allergen.
In conclusion, the results presented in this paper
demonstrate further that the LLNA provides quantitative information on
skin sensitizing potency which is predictive of allergenic potency in
humans. Such data promises to be a valuable tool for hazard
characterization and for risk assessment.
Based on the results of this study the Cyclamen
Aldehyde is classified as a weak sensitiser (Cat 1B)
The study was performed according to the local lymph node assay
method to assess the skin sensitisation potential of the test item in
the CBA/Ca strain mouse following topical application to the dorsal
surface of the ear. The test item was tested at concentrations of: 0.1%,
0.5%, 1%, 2.5%, 5%, 10%, 25% and 50% (w/v) in acetone/olive oil (4:1)
and with a 0% vehicle control group. The SI values calculated for the
test item concentrations 0.1%, 0.5%, 1%, 2.5%, 5%, 10%, 25% and 50% were
0, 0, 1.4, 1.34, 0, 1.84, 3.26, and 5.16 respectively. The results show
that the test item elicited an SI ≥ 3 and resulted in a calculated EC3
value of 22.3 % (w/v). Under the conditions of this study, the test item
was found to be a weak skin sensitiser (Cat 1B) based on GHS
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