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EC number: 203-161-7
CAS number: 103-95-7
Based on the time-weighted mean measured test concentrations the 48-Hour EC50 was 1.4 mg/L; 95% confidence limits 0.63 – 7.6 mg/L. The No Observed Effect Concentration was 0.046 mg/L.
Two studies are available on the short-term
toxicity of cyclamen aldehyde to aquatic invertebrates. The determined
48 hour EC50 values are 1.4 mg/L (key study, Harlan 2012) and 4.19 mg/L
(supporting study, Noack 2000). The Harlan (2012) study was considered more
reliable since it was performed under semi-static conditions with the
concentration and stability of the test item in the test preparations
verified by chemical analysis at 0 and 24 hours (fresh media), and at 24
and 48 hours (old media). In contrast, the Noack (2000) study was performed
under static conditions and the concentration of the test item was only analytically
verified at the start of the test. The details of the key study are summarised
The method followed was designed to be
compatible with the US EPA Draft Ecological Effects Test Guidelines
OPPTS 850.1010 and the OECD Guidelines for Testing of Chemicals (April
2004) No 202, "Daphnia sp., Acute Immobilisation Test" referenced as
Method C.2 of Commission Regulation (EC) No. 440/2008.
The test item was known to be volatile
(EPIWIN V3.20 predicted Henry’s law constant greater than 100 Pa.m3/mol)
and hence it was likely that losses of test item would occur during the
time taken to prepare the required test concentrations. As such, samples
were taken for immediate chemical analysis to minimize losses as far as
practically possible. Analysis of the freshly prepared test preparations
showed measured test concentrations to range from 0.018 to 1.4 mg/L at 0
hours and from 0.013 to 1.6 mg/L at 24 hours. A decline in measured test
concentration was observed in the old or expired test media in the range
of less than the limit of quantitation (LOQ) of the analytical method
employed which was determined to be 0.013 mg/L to 1.1 mg/L at 24 hours
and from less than the LOQ to 0.99 mg/L at 48 hours.
Given this decline in measured test
concentrations it was considered justifiable to base the results on the
time-weighted mean measured test concentrations in order to give a
"worst case" analysis of the data.
The 48-Hour EC50 based on the time-weighted
mean measured test concentrations was 1.4 mg/L; 95% confidence limits
0.63 – 7.6 mg/L. The No Observed Effect Concentration was 0.046 mg/L.
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