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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Study initiation date : April 11, 2011 Start of experiments: April 18, 2011 End of experiments : April 18, 2011 Study completion date: May 12, 2011
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and /or mimnor methodological deficiencies, which do not affect the quality of relevant results.
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
3.4
Temp.:
35 °C
pH:
ca. 7
Remarks on result:
other:
Remarks:
The determination was performed at 35 °C (temperature of the column), but the value obtained above can be considered to represent the value at an unspecified, probably ambient temperature since no mention is made in the guidelines of the temperature at which the tabulated reference substances log Pow values were determined. Partition coefficients of the test and reference substances are assumed to vary with temperature in the same way.
Details on results:
Detailed results are given in Appendix 1 and illustrated by the graph in appendix 2 in attachment 1.

The chromatogram shows one peak at retention time 9.12 minutes, corresponding to a partition coefficient (Log value) of 3.4.

Therefore , the Partition Coefficient n-octanol/water of Cyclamen Aldehyde Extra: Log Pow = 3.4

Conclusions:
Partition Coefficient n-octanol/water of Cyclamen Aldehyde Extra was determined to be Log Pow = 3.4
Executive summary:

The Partition Coeffiecient n-octanol/water of Cyclamen Aldehyde was determined by the Reverse Phase High Performance Liquid Chromatographic Method according to the OECD Guidelines for Testing of Chemicals, Method No. 117.

Partition Coefficient n-octanol/water of Cyclamen Aldehyde Extra was determined to be Log Pow = 3.4

Description of key information

Partition coefficient Log Pow = 3.4 (OECD 117)

Key value for chemical safety assessment

Log Kow (Log Pow):
3.4
at the temperature of:
35 °C

Additional information

The Partition Coeffiecient n-octanol/water of Cyclamen Aldehyde was determined by the Reverse Phase High Performance Liquid Chromatographic Method according to the OECD Guidelines for Testing of Chemicals, Method No. 117.

Partition Coefficient n-octanol/water of Cyclamen Aldehyde Extra was determined to be Log Pow = 3.4.

(The determination was performed at 35 °C (temperature of the column) but the value obtained can be considered to represent the value at an unspecified, probably ambient temperature since no mention is made in the guidelines of the temperature at which the tabulated reference substances log Pow values were determined).

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