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EC number: 203-161-7
CAS number: 103-95-7
The PNECaqua (freshwater) for the aquatic environment is derived from the lowest effect level observed for the available chronic end-points (for D. magna, NOEC = 0.44 mg/L) and applying an assessment factor of 50, to obtain the PNEC aqua (freshwater) of 8.8 ppb.
The PNEC aqua (intermittent) is derived from the lowest short-term exposure EC/LC50 (1.4 mg/L, 48hr EC50 for D. magna) and an assessmentactor of 100 is applied to obtain the PNEC aqua (intermittent) of 14 ppb.
No marine species were tested. No tests on toxicity to sediment-dwelling organisms or soil organisms are available
PNECs for sediment and soil are calculated from the aquatic PNECs with the equilibrium partitioning method according to ECHA guidance R.10.
PNEC sediment (freshwater/marine water): Wet weight PNECs are calculated with Ksusp-water = 28.95 m3/m3, density of suspended particles = 1150 kg/m3 (wet weight); conversion to dry weight is done with factor of 4.6. (PNEC sediment freshwater = 0.222 mg/kg wet weight; PNEC sediment marine water = 0.0222 mg/kg wet weight).
PNEC soil: Wet weight PNECs are calculated with Ksoil-water = 34.06 m3/m3, density of soil = 1700 kg/m3 (wet weight); conversion to dry weight is done with factor of 1.13 (PNEC soil = 0.175 mg/kg wet weight).
PNEC secondary poisoning was derived from the available information on repeated dose toxicity (OECD 408) NOAEL 30 mg/kg bw/day with R. norvegicus converting to a concentration (NOEC) by multiplying by a factor of 20 and dividing by an assessment factor of 90 (90 day study) in accordance with ECHA R.10.8.
Environmental classification and labelling of a substance is generally based on data from short-term aquatic toxicity results, the ready biodegradability of the substance and the measured octanol/water partition coefficient. Available adequate chronic toxicity data is also relevant for the assessment of long-term aquatic hazards (Regulation 286/2011/EC).
Short-term aquatic toxicity data is available for all three trophic levels. The lowest short-term L(E)C50 was for Daphnia with a 48h EC50 of 1.4 mg/L. Chronic aquatic toxicity data is only available for algae and Daphnia; the 72-hour NOEC and EC10 are, respectively, 0.72 mg/L and 2.6 mg/L (based on growth rate), and, the NOEC for Daphnia reproduction has been derived as 0.44 mg/L using a robust read-across approach to a close structural analogue. Cyclamen aldehyde is readily biodegradable and has a log Kow of 3.4.
Based on the above data, Cyclamen aldehyde is classified as R51/53 according to Directive 67/548/EEC (DSD) and Aquatic Chronic 3 (H412) according to the CLP Regulation 1272/2008/EC & adaptation 286/2011/EC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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