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EC number: 404-950-0
CAS number: 21369-64-2
of live offspring of the Filial generation (F1) derived from parent
animals alive at the end of the test of the control and test
concentrations of 0.25 to 16.0 mg/L; mean-value, standard deviation (SD)
and variation coefficient (Vc):
0.25 mg/L *
0.5 mg/L *
1.0 mg/L *
2.0 mg/L *
4.0 mg/L *
8.0 mg/L *
16.0 mg/L *
nominal concentration of Lithium hydroxide monohydrate
Significant difference compared to the control according to Dunnett`s
test (p = 0.05).
A semi-static Daphnia magna reproduction
test was performed according to OECD Guideline 211. At this method
Daphnia magna, aged lower or equal 24 h at the beginning of the test,
are exposed to a range of Lithium hydroxide monohydrate under defined
conditions over a period of 21 days. The test item is a solid that is
soluble in water and therefore, no solvent was used. The test solutions
were prepared in a dilution series from a stock solution of 100 mg/L of
the test item in culturing medium. In the definitive test the nominal
concentrations were as follows: 0.25, 0.5, 1.0, 2.0, 4.0, 8.0 and 16.0
mg/L. Analysis of the test solutions for lithium confirmed that the test
solutions were correctly dosed and stable during the exposure period
(recoveries ranging from 95.5 to 102 % of nominal concentrations for the
freshly prepared and aged test solutions). Therefore, the concentrations
were reported as nominal concentrations. The Test item Lithium hydroxide
monohydrate caused a statistically significant effect on live offspring
of the Filial generation (F1) derived from the parent animals surviving
at the end of the test at nominal test concentration of 8.0 mg Lithium
hydroxide monohydrate/L according to Dunnett`s test (p = 0.05).
Therefore, the NOEC determined on
reproduction for Lithium hydroxide monohydrate was 4.0 mg/L and the LOEC
was 8.0 mg/L.
Based on read across approach, the
calculated NOEC for n-Hexyllithium was 9 mg/L.
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