Registration Dossier
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EC number: 930-993-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1991-08
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- GLP guideline study; no analytical monitoring was performed in the study Further, the test medium was not modified as recommended in the OECD guideline to take into consideration that zeolites have strong effects on the availability of nutrients or minerals. For strongly absorbing substances like zeolites, the actual OECD guideline proposes a modification of the test medium in offering a nutrient-rich medium.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report Date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- GLP compliance:
- yes
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- - Name of test material (as cited in study report): Wessalith P
- Related CAS number: 1318-02-1
- Chemical name: Natrium-Aluminiumsilikat
- Framework: monoclinic
- Analytical purity: 79,8%
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- no
- Details on test solutions:
- As the test substance contained insoluble matter, water accomodated fractions and their filtrate were tested.
To adjust the desired concentrations, test material was directly weighed in algal medium, stirred for one hour and filtered (Whatman GF/C glass microfibre filter, d=4.7 mm, the first 200 mL of the filtrate discarded) prior to test.
Test organisms
- Test organisms (species):
- Desmodesmus subspicatus (previous name: Scenedesmus subspicatus)
- Details on test organisms:
- -strain: SAG 86.81
- source: Institute for Plant Physiology, University of Göttingen, Germany
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- no data
- Test temperature:
- 23+/-1°C
- pH:
- Initial pH was 8.9, it increased with algal density to 8.6 - 10.6 after 4 days.
- Dissolved oxygen:
- no data
- Nominal and measured concentrations:
- Following concentrations were tested: 0, 2.9, 10.5, 38, 103 and 328 mg/L.
- Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 18 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: Unfiltered dispersion, particle counting
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 34 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: Unfiltered dispersion, fluorescence measurements
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 10 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks on result:
- other: Unfiltered dispersions
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 34 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Remarks on result:
- other: Unfiltered dispersion, particle counting
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 45 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Remarks on result:
- other: Unfiltered dispersion, fluorescence measurements
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 328 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- eluate
- Basis for effect:
- growth rate
- Remarks on result:
- other: Filtered solutions
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 328 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- eluate
- Basis for effect:
- biomass
- Remarks on result:
- other: Filtered solutions
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 38 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- eluate
- Remarks on result:
- other: Filtered solutions
Any other information on results incl. tables
Reported data relate to unfiltered suspension, endpoint growth yield, measured by particle counting.
Summary of all results (range between tested concentrations):
I) Unfiltered dispersion, particle counting
growth yield area under growth curve
(=biomass)
EC10 4.9 5.7 (2.9-10.5)
EC50 18 (10-32) 34 (10.5-38)
EC90 66 130 (105-328)
II) Unfiltered dispersion, fluorescence measurement
growth yield area under growth curve
(=biomass)
EC10 11 12 (10.5-38)
EC50 34 (28-52) 45 (38-103)
EC90 84 200 (105-328)
III) Filtered solution, particle counting
growth rate area under growth curve
(=biomass)
EC10 >328 77 (38-103)
EC50 >328 >328
EC90 >328 >328
Note: There is a typo in table 1 of the report; growth rate for filtered solutions should read 0.072 instead of 0.72. The results refer to nominal concentrations of the test substance.
By visual comparison of the measured and the calculated growth curves of algal suspensions exposed to the test substance with those of the algal controls, the NOEC of the test item was estimated to be 38 mg/L (filtered test substance) and 10 mg/L (unfiltered test substance).
Filtered test substance solutions appeared to be much less toxic than unfiltered ones. This is explained by leaching of toxic components from particles during the test with unfiltered samples. However, turbid test solutions also result in reduced light supply, and to an increased binding of nutrients by the test substance.
Microscopic examination of the cells showed that algal cells in the unfiltered 10E3 mg/L solutions were coagulated with test substance particles at the end of the test.
Applicant's summary and conclusion
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