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EC number: 457-310-8
CAS number: 127733-97-5
PLATINUM(2+), TETRAAMMINE-, (SP-4-1)-, DIACETATE (9CI)
Environmental classification for the tetraammineplatinum(II) substances under consideration is based on the lowest acute and chronic threshold values from the tetraammineplatinum(II) ecotoxicity test data:
-acute ERV: lowest acute threshold value is 8.6 mg Pt/L (geometric mean EC50 value with D. magna, based on the experimental results for tetraammineplatinum diacetate and tetraammineplatinum dihydrogencarbonate)
-chronic ERV: lowest chronic threshold value is 1.41 mg Pt/L (lowest EC10 value for toxicity to algae observed for tetraammineplatinum acetate).
The derivation of both ERV values is detailed in the read-across justification report (cfr. IUCLID Section 13).
For classification purposes, these ERVs have been recalculated to the values expressed as the concentration of the substance (conversion based on molecular weight conversion from soluble ion to the substance considered – cfr. details in below table). Environmental classification is derived as outlined in ECHA Guidance on the application of the CLP criteria (version 5.0; ECHA, 2017) - cfr. below table.
using acute ERV
using chronic ERV
Acute ERV(mg TI/L)
Chronic ERV(mg TI/L)
Acute aquatic hazard
Long-term aquatic hazard
Aquatic Chronic 3
Tetraammineplatinum(II) hydrogen carbonate
Environmental classification is assessed:
-for acute toxicity: based on the acute ERV for the category
-for chronic toxicity: based on the acute and chronic ERVs for the category. As highlighted in the read-across justification document, chronic data are only available for algae. This algae tox data are the basis for the chronic ERV. However, for classification purposes, the classification using the more reliable acute ERV is also derived and the most conservative classification is maintained. All substances covered in this category are classified as Aquatic Chronic 3 (H412) based on the acute ERV. No classification for acute aquatic hazard is required (acute ERV > 1 mg/L).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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