Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 457-310-8
CAS number: 127733-97-5
PLATINUM(2+), TETRAAMMINE-, (SP-4-1)-, DIACETATE (9CI)
Mean 24 -72 hours
Table 1: Mean value eye irritation scores
an OECD guideline study (TG 405), conducted according to GLP,
approximately 93 mg of platinum (2 +) tetraammine (SP-4 -1) diacetate
was instilled into one eye of each of three male New Zealand white
rabbits. The other eye remained untreated and was used for control
of the conjunctivae, consisting of redness, chemosis and discharge
(highest scores observed in an individual rabbit were 3, 2, 2
respectively) was observed in all three animals. The irritation had
completely resolved within 14 days. No effects were seen on the iris or
cornea. No corrosive effects were noted and there was no evidence of
systemic toxicity. As the conjunctival redness score (calculated as mean
of the scores at 24, 48 and 72 hr) was greater than or equal to 2 in all
three animals, the test material met the criteria for classification as
irritant category 2 according to EU CLP regulations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again