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EC number: 457-310-8
CAS number: 127733-97-5
PLATINUM(2+), TETRAAMMINE-, (SP-4-1)-, DIACETATE (9CI)
acute dermal toxicity of tetraammineplatinum(II) diacetate was
investigated in a protocol conducted according to OECD Test Guideline
402 and to GLP. The test substance was applied under occlusion to the
skin of Wistar rats (5/sex) at a limit dose of 2000 mg/kg bw for 24
hours. After this period, dressings were removed and the skin was washed
with water. Animals were then monitored over the next two weeks for
mortality and any clinical signs of toxicity. After this period, any
survivors were sacrificed, and subjected to gross necropsy.
mortality occurred during the experiment, and no macroscopic
abnormalities were found at post mortem. No body weight changes
indicative of toxicity were observed. Clinical signs included hunched
posture, bloody tears, lethargy, shallow respiration and piloerection.
In the treated skin area, general, focal or maculate erythema, scales,
scabs, scars and/or necrosis were apparent. Hence the acute dermal LD50
value of tetraammineplatinum(II) diacetate was determined to exceed 2000
mg/kg bw in rats.
on the results of this study, tetraammineplatinum
diacetate does not require classification for acute dermal toxicity
according to EU CLP criteria (EC 1272/2008).
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