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EC number: 457-310-8
CAS number: 127733-97-5
PLATINUM(2+), TETRAAMMINE-, (SP-4-1)-, DIACETATE (9CI)
Skin irritation reactions were graded 0
(corresponding to "no erythema" and "no oedema") for all tested animals
at all doses.
an OECD Test Guideline 429 local lymph node assay (LLNA), conducted to
GLP, 25 µl tetraammineplatinum(II) diacetate in propylene glycol
was applied once daily to the skin of both ears of female CBA mice
(5/group), at 0, 5, 25 or 50%, for three consecutive days. Mice were
monitored for mortality and overt signs of toxicity, as well as changes
in body weight. Skin irritation was assessed and graded three to four
hours after the final dose (on day three). Three days after this
induction period (on day six), mice were given tail vein injections of
radiolabelled thymidine, and were sacrificed after approximately five
hours. Lymph nodes were excised and processed for radioactivity.
skin irritation was observed and lymph nodes were a normal size, with
the exception of one animal given the test substance at 25% and showing
eye abnormalities. The anomalous results for this animal were
subsequently discounted. No mortality or substance-related toxicity was
observed over the course of the experiment. SI values were 1.4, 1.3 and
2.4 for animals given respective concentrations of 5%, 25% and 50%. An
SI value of over 3 was judged to be indicative of a substance being
sensitising. Hence, under the conditions of this assay,
tetraammineplatinum diacetate was considered non-sensitising.
on the results of this study, tetraammineplatinum(II)
diacetate does not require classification for skin sensitisation
according to EU CLP criteria (EC 1272/2008).
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