Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-255-2 | CAS number: 80-17-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- BG Chemie - Potential Health Hazards of Existing Chemiclas (TOXIKOLOGISCHE BEWERTUNG zu Benzolsulfonsäurehydrazid, BG-Nr. 220)
- Author:
- Berufsgenossenschaft Rohstoffe und chemische Industrie (BG RCI)
- Reference Type:
- publication
- Title:
- Toxicity of rubber chemicals towards three-day chicken embryos
- Author:
- Korhonen A, Hemminki K, Vainio H
- Year:
- 1 983
- Bibliographic source:
- Scand J Work Environ Health 1983;9(2):115-119
Materials and methods
- GLP compliance:
- not specified
Test animals
- Species:
- other: chicken
- Strain:
- other: white Leghorn
- Details on test animals or test system and environmental conditions:
- 3 day old chicken embryos (white Leghorn)
Administration / exposure
- Route of administration:
- infusion
- Vehicle:
- acetone
- Details on exposure:
- 75% BSH in paraffin oil dissolved in acetone was administered at concentrations of 1.0, 2.0, 3.0 and 4.0 µmol/egg into the air chamber of 3 day old chicken embryos (white Leghorn). The injection volume was 1 µl.
- Duration of treatment / exposure:
- 11 days
- Duration of test:
- 14-day incubation period
- No. of animals per sex per dose:
- 30 eggs were used for each concentration.
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- At the end of the 14-day incubation period (11 days after administration), the embryotoxic potency was evaluated according to the total number of embryos affected 11 days after administration, using overall mortality and the number of malformed embryos (total effect) as a basis.
Results and discussion
Results (fetuses)
Effect levels (fetuses)
- Key result
- Dose descriptor:
- other: median effect dose (ED50)
- Effect level:
- 2.6 other: µmol/egg
- Based on:
- test mat.
- Basis for effect level:
- other: malformations and mortality
Any other information on results incl. tables
At 1.0 µmol, 13% of the treated eggs were affected, at 2.0 and 3.0 µmol 47% and at 4.0 µmol this figure was 70%. From these vlaues, an ED50 (total effect) of 2.6 µmol/egg (confidence range 2.1 to 3.3 µmol) was determined over the 11 days following application. The malformations were described as 2 different types of eye defect and (reduced eye cup and partial or complete absence of lids and cornea), defects of the coelum wall and generalized oedema. The highest mortality rate (46%) and malformation rate (43%) determined occured in the (dead and surviving) embryos treated with 4.0 µmol/egg.
Applicant's summary and conclusion
- Conclusions:
- It is almost impossible to apply these findings to mammalian systems since the absorption barriers and detoxification mechanisms in the latter are not taken into account.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.