Registration Dossier

Administrative data

Endpoint:
carcinogenicity: oral
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
BG Chemie - Potential Health Hazards of Existing Chemiclas (TOXIKOLOGISCHE BEWERTUNG zu Benzolsulfonsäurehydrazid, BG-Nr. 220)
Author:
Berufsgenossenschaft Rohstoffe und chemische Industrie (BG RCI)
Reference Type:
publication
Title:
A study of certain substituted sulphonohydrazides for carcinogenicity in mice
Author:
R. J. W. Cremlyn, F.J.C. Roe
Year:
1971
Bibliographic source:
R.J.W. Cremlyn, F.J.C. Roe, A study of certain substituted sulphonohydrazides for carcinogenicity in mice, Food Cosmet. Toxicol., 9, 2, 1971, 319-320,

Materials and methods

GLP compliance:
not specified

Test animals

Species:
mouse
Strain:
Swiss
Sex:
female
Details on test animals and environmental conditions:
8 weeks ol at the start of the study

Administration / exposure

Route of administration:
other: gastric instillation
Vehicle:
other: aqueous gelatin
Remarks:
2 mg BSH in 0.2 ml 3% aqueous gelatin
Details on exposure:
5 doses/week for 4 wk, followed by 3 doses/week to a total of 158 doses (also for control group)

Results and discussion

Any other information on results incl. tables

After 60 weeks, the surviving animals were examined for tumours.

Among 24 mice there were 4 lung tumors (controls 1/29) and 4 liver tumours (controls 1/29).

No further details of the distribution of the tumours and the hispathological findings were available.

Applicant's summary and conclusion

Conclusions:
Benzene sulphonic acid hydrazide may have marginal tumorigenic activity in mice, but is not a strong carcinogen.