Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 201-255-2 | CAS number: 80-17-1
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- BG Chemie - Potential Health Hazards of Existing Chemiclas (TOXIKOLOGISCHE BEWERTUNG zu Benzolsulfonsäurehydrazid, BG-Nr. 220)
- Author:
- Berufsgenossenschaft Rohstoffe und chemische Industrie (BG RCI)
Materials and methods
- GLP compliance:
- not specified
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Remarks:
- male and female (3-4 kg)
Test system
- Amount / concentration applied:
- 50 mg
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 2 of each sex
Results and discussion
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No evidence of an irritant effect on the eye during the 7-day post-treatment observation period following administration of 50 mg into the conjunctival sac of 2 rabbits of each sex (irritant value 0).
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