Registration Dossier

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
review article or handbook
Title:
BG Chemie - Potential Health Hazards of Existing Chemiclas (TOXIKOLOGISCHE BEWERTUNG zu Benzolsulfonsäurehydrazid, BG-Nr. 220)
Author:
Berufsgenossenschaft Rohstoffe und chemische Industrie (BG RCI)

Materials and methods

GLP compliance:
not specified

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White
Remarks:
male and female (3-4 kg)

Test system

Amount / concentration applied:
50 mg
Observation period (in vivo):
7 days
Number of animals or in vitro replicates:
2 of each sex

Results and discussion

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
No evidence of an irritant effect on the eye during the 7-day post-treatment observation period following administration of 50 mg into the conjunctival sac of 2 rabbits of each sex (irritant value 0).