Registration Dossier

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
review article or handbook
Title:
BG Chemie - Potential Health Hazards of Existing Chemiclas (TOXIKOLOGISCHE BEWERTUNG zu Benzolsulfonsäurehydrazid, BG-Nr. 220)
Author:
Berufsgenossenschaft Rohstoffe und chemische Industrie (BG RCI)

Materials and methods

GLP compliance:
not specified

Test animals

Species:
rat
Strain:
Wistar
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
polyethylene glycol
No. of animals per sex per dose:
10 animals/dose group

Results and discussion

Effect levels
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
160 mg/kg bw
Clinical signs:
tremors, clonical spasms, jumping and aggressiveness, poor general condition (100 mg/kg bw and more)

Applicant's summary and conclusion

Interpretation of results:
Category 3 based on GHS criteria