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EC number: 201-328-9
CAS number: 81-14-1
In a reverse gene mutation assay in bacteria (QC11WT), strains of S.
typhimurium TA 1535, TA 1537, TA 98, TA 100 and E. coli WP2 uvr A were
exposed to musk ketone (99.8%) in DMSO at concentrations of 1.5, 5, 15,
50, 150, 500, 1500 and 5000μg/plate (plate incorporation; experiment 1)
and 15, 50, 150, 500, 1500, 5000 μg/plate (20 minute pre-incubation;
experiment 2) in the presence and absence of mammalian metabolic
activation (Phenobarbital/β-naphthoflavone-induced rat liver S9).
Musk ketone was tested up to the limit concentration (5000 µg/plate).
The positive controls induced the appropriate responses in the
corresponding strains. There was no evidence of induced mutant colonies
This study is classified as acceptable. This study satisfies the
requirement for Test Guideline OECD 471 for in vitro mutagenicity
(bacterial reverse gene mutation) data.
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