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EC number: 201-328-9
CAS number: 81-14-1
In an acute oral toxicity study (55049), Sprague-Dawley rats
(5/dose/sex) were given musk ketone in corn oil by gavage at doses of
5000 mg/kg bw and observed for 14 days.
LD50 (male/female): was >5000 mg/kg bw.
No mortality was observed in male or female rats during the study. All
animals exhibited sedation and/or piloerection at 1 hour following
intubation, and tremors, some sedation, and respiratory abnormalities
(depression and short, rapid respiration) at 3 and 6 hours following
intubation. Test animals showed no toxic signs on day 1, and continued
to remain normal during the remainder of the 14-day observation period.
Body weights at days 0 and 14 were within a normal range for both male
and female animals. A single animal had an enlarged spleen; otherwise,
no gross pathological organ changes were observed in any animals.
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