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EC number: 201-328-9
CAS number: 81-14-1
In dermal absorption and disposition studies of musk ketone (Hawkins and
Ford, 1999), Sprague–Dawley CD and Long Evans male rats were
administered nominal doses of 0.5 mg/kg bw of ring-labelled 14C-musk
ketone (98%; in a mixture of phenylethyl alcohol and ethanol) for 6
hours (acute study) and monitored up to 120 hr post-dosing and 14
repeated daily doses of 0.5 mg/kg bw of ring-labelled 14C-musk ketone.
Bile duct cannulation (1 rat) was also performed in the acute study and
bile and urine were collected at 24 hrs. Faeces and urine were collected
during both studies and blood, brain, kidneys, liver, thyroid and
perirenal fat were retained for analysis. Thin layer chromatography and
mass spectrometry was performed to identify metabolites.
Mean dermal absorption values for the acute treatment group for which
the skin site was washed after 6 hours with sacrifice at 120 hrs (n=3),
was 31.3%. In the acute disposition study, fat and liver contained the
highest concentrations with concentrations declining fairly rapidly
until 120 h when levels were at similar levels to other tissues.
Excretion after 14 day repeated dosing was mainly in the faeces (11.7%
compared to 2.7% in urine). In urine samples taken after 14 day repeated
treatments, most of the metabolites were not simple conjugates such as
glucuronides and sulphates but could not be further identified. Analysis
of bile samples did however show the presence of polar metabolites,
which appeared to consist almost entirely of glucuronide conjugates.
There is some bioaccumulation after repeated daily dosing however it is
not likely that this would continue over longer periods of time.
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